Matches in SemOpenAlex for { <https://semopenalex.org/work/W66059530> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W66059530 endingPage "367" @default.
- W66059530 startingPage "355" @default.
- W66059530 abstract "Bacteroides forsythus is one of the etiologic agents of destructive periodontal diseases. Determining which antigenic components of the bacterium are recognized in the immune response of periodontitis patients is an important step in assessing strategies for vaccine development. The aim of this study was to identify the major strain-variable and cross-reactive antigens of B. forsythus clinical isolates recognized by serum IgG from patients with early-onset rapidly progressive periodontitis. Ten patient sera with measurable IgG against antigenic components of the species were identified by Western blot. Positive sera were tested by checkerboard ELISA to identify those most responsive to strain-variable antigens in nine clinical isolates and ATCC strain 43037. Correlation analysis of the ELISA data suggested that different subsets of isolates were preferentially recognized by different sera. Western blots revealed that certain sera also recognized major shared components across all the isolates, but preferential recognition of different isolate subsets by different patients was clearly confirmed. To determine if the variable antigens recognized were nonprotein, proteinase K-digested isolates were compared to undigested controls by Western blot. The main strain-variable antigens were proteinase resistant, while proteins at 200 and 210 kDa were identified as the major shared components. Two-dimensional SDS-PAGE revealed that these proteins are the quantitatively dominant heat-modifiable components of the cell envelope. Even though variable antigens are prominent in the immune response of patients, a cross-protective vaccine based on the shared envelope proteins of B. forsythus seems feasible in light of these observations." @default.
- W66059530 created "2016-06-24" @default.
- W66059530 creator A5006600033 @default.
- W66059530 creator A5008122431 @default.
- W66059530 creator A5022817074 @default.
- W66059530 creator A5033928415 @default.
- W66059530 creator A5038389218 @default.
- W66059530 date "1998-01-01" @default.
- W66059530 modified "2023-09-27" @default.
- W66059530 cites W1559273085 @default.
- W66059530 cites W1762697277 @default.
- W66059530 cites W1837256871 @default.
- W66059530 cites W1900702673 @default.
- W66059530 cites W1932191072 @default.
- W66059530 cites W1952620523 @default.
- W66059530 cites W1974854584 @default.
- W66059530 cites W2018289835 @default.
- W66059530 cites W2022157749 @default.
- W66059530 cites W2025198251 @default.
- W66059530 cites W2030547851 @default.
- W66059530 cites W2069355914 @default.
- W66059530 cites W2101108802 @default.
- W66059530 cites W2134645893 @default.
- W66059530 cites W2140049855 @default.
- W66059530 cites W2153829240 @default.
- W66059530 cites W2409950745 @default.
- W66059530 cites W4231263783 @default.
- W66059530 doi "https://doi.org/10.1023/a:1023295000295" @default.
- W66059530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9793828" @default.
- W66059530 hasPublicationYear "1998" @default.
- W66059530 type Work @default.
- W66059530 sameAs 66059530 @default.
- W66059530 citedByCount "6" @default.
- W66059530 crossrefType "journal-article" @default.
- W66059530 hasAuthorship W66059530A5006600033 @default.
- W66059530 hasAuthorship W66059530A5008122431 @default.
- W66059530 hasAuthorship W66059530A5022817074 @default.
- W66059530 hasAuthorship W66059530A5033928415 @default.
- W66059530 hasAuthorship W66059530A5038389218 @default.
- W66059530 hasBestOaLocation W660595301 @default.
- W66059530 hasConcept C104317684 @default.
- W66059530 hasConcept C147483822 @default.
- W66059530 hasConcept C159047783 @default.
- W66059530 hasConcept C159654299 @default.
- W66059530 hasConcept C203014093 @default.
- W66059530 hasConcept C2776415932 @default.
- W66059530 hasConcept C2778168646 @default.
- W66059530 hasConcept C523546767 @default.
- W66059530 hasConcept C54355233 @default.
- W66059530 hasConcept C85265743 @default.
- W66059530 hasConcept C86803240 @default.
- W66059530 hasConcept C8891405 @default.
- W66059530 hasConcept C89423630 @default.
- W66059530 hasConceptScore W66059530C104317684 @default.
- W66059530 hasConceptScore W66059530C147483822 @default.
- W66059530 hasConceptScore W66059530C159047783 @default.
- W66059530 hasConceptScore W66059530C159654299 @default.
- W66059530 hasConceptScore W66059530C203014093 @default.
- W66059530 hasConceptScore W66059530C2776415932 @default.
- W66059530 hasConceptScore W66059530C2778168646 @default.
- W66059530 hasConceptScore W66059530C523546767 @default.
- W66059530 hasConceptScore W66059530C54355233 @default.
- W66059530 hasConceptScore W66059530C85265743 @default.
- W66059530 hasConceptScore W66059530C86803240 @default.
- W66059530 hasConceptScore W66059530C8891405 @default.
- W66059530 hasConceptScore W66059530C89423630 @default.
- W66059530 hasIssue "5" @default.
- W66059530 hasLocation W660595301 @default.
- W66059530 hasLocation W660595302 @default.
- W66059530 hasOpenAccess W66059530 @default.
- W66059530 hasPrimaryLocation W660595301 @default.
- W66059530 hasRelatedWork W1484759019 @default.
- W66059530 hasRelatedWork W1856873384 @default.
- W66059530 hasRelatedWork W1972479046 @default.
- W66059530 hasRelatedWork W2014992398 @default.
- W66059530 hasRelatedWork W2045616199 @default.
- W66059530 hasRelatedWork W2147811449 @default.
- W66059530 hasRelatedWork W2150135081 @default.
- W66059530 hasRelatedWork W2220102944 @default.
- W66059530 hasRelatedWork W2332754668 @default.
- W66059530 hasRelatedWork W4313376859 @default.
- W66059530 hasVolume "18" @default.
- W66059530 isParatext "false" @default.
- W66059530 isRetracted "false" @default.
- W66059530 magId "66059530" @default.
- W66059530 workType "article" @default.