Matches in SemOpenAlex for { <https://semopenalex.org/work/W66148929> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W66148929 endingPage "5" @default.
- W66148929 startingPage "S61" @default.
- W66148929 abstract "High levels of recombinant activated factor VII (rFVIIa; NovoSeven, Novo Nordisk, Bagsvaerd, Denmark) have been found to be effective in providing haemostasis in haemophiliacs and in normal individuals with acquired inhibitors to factor VIII (FVIII) or FIX. However, the mechanism of this therapeutic effect of FVIIa is unclear. Opinion is divided over whether high-dose FVIIa therapy works primarily by a tissue factor (TF)-dependent or -independent mechanism. Our group originally favoured a TF-dependent mechanism; however, we have recently found that, at levels comparable with those attained therapeutically, FVIIa activates enough FX on activated platelets to restore platelet surface thrombin generation. These data now lead us to favour a primarily (although not necessarily exclusively) TF-independent mechanism for the haemostatic effect of high-dose FVIIa. We believe that a platelet surface localization of FVIIa activity explains both its safety and efficacy, as well as its haemostatic effect in patients with thrombocytopenia and platelet function defects. Localization on activated platelets would tend to restrict the activity of FVIIa to sites of injury. Activation of FX on the platelet surface in haemophiliacs would provide FXa in a favourable location to escape inhibition by plasma protease inhibitors and be incorporated into platelet prothrombinase complexes. Activation of FIX and FX on platelet surfaces in thrombocytopenia would result in more thrombin generation per platelet, possibly leading to formation of a stable fibrin network even in the absence of an optimal initial platelet plug." @default.
- W66148929 created "2016-06-24" @default.
- W66148929 creator A5029402886 @default.
- W66148929 creator A5051841089 @default.
- W66148929 creator A5087076296 @default.
- W66148929 date "1998-03-01" @default.
- W66148929 modified "2023-09-29" @default.
- W66148929 title "Activated factor VII activates factors IX and X on the surface of activated platelets: thoughts on the mechanism of action of high-dose activated factor VII." @default.
- W66148929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9819030" @default.
- W66148929 hasPublicationYear "1998" @default.
- W66148929 type Work @default.
- W66148929 sameAs 66148929 @default.
- W66148929 citedByCount "81" @default.
- W66148929 countsByYear W661489292012 @default.
- W66148929 countsByYear W661489292013 @default.
- W66148929 countsByYear W661489292014 @default.
- W66148929 countsByYear W661489292015 @default.
- W66148929 countsByYear W661489292016 @default.
- W66148929 countsByYear W661489292017 @default.
- W66148929 countsByYear W661489292018 @default.
- W66148929 countsByYear W661489292019 @default.
- W66148929 countsByYear W661489292020 @default.
- W66148929 countsByYear W661489292022 @default.
- W66148929 countsByYear W661489292023 @default.
- W66148929 crossrefType "journal-article" @default.
- W66148929 hasAuthorship W66148929A5029402886 @default.
- W66148929 hasAuthorship W66148929A5051841089 @default.
- W66148929 hasAuthorship W66148929A5087076296 @default.
- W66148929 hasConcept C112516734 @default.
- W66148929 hasConcept C126322002 @default.
- W66148929 hasConcept C185592680 @default.
- W66148929 hasConcept C186738567 @default.
- W66148929 hasConcept C202751555 @default.
- W66148929 hasConcept C203014093 @default.
- W66148929 hasConcept C2776120743 @default.
- W66148929 hasConcept C2777292125 @default.
- W66148929 hasConcept C2777444498 @default.
- W66148929 hasConcept C2778382381 @default.
- W66148929 hasConcept C2910886357 @default.
- W66148929 hasConcept C3018697912 @default.
- W66148929 hasConcept C54173615 @default.
- W66148929 hasConcept C55493867 @default.
- W66148929 hasConcept C71924100 @default.
- W66148929 hasConcept C89560881 @default.
- W66148929 hasConcept C98274493 @default.
- W66148929 hasConceptScore W66148929C112516734 @default.
- W66148929 hasConceptScore W66148929C126322002 @default.
- W66148929 hasConceptScore W66148929C185592680 @default.
- W66148929 hasConceptScore W66148929C186738567 @default.
- W66148929 hasConceptScore W66148929C202751555 @default.
- W66148929 hasConceptScore W66148929C203014093 @default.
- W66148929 hasConceptScore W66148929C2776120743 @default.
- W66148929 hasConceptScore W66148929C2777292125 @default.
- W66148929 hasConceptScore W66148929C2777444498 @default.
- W66148929 hasConceptScore W66148929C2778382381 @default.
- W66148929 hasConceptScore W66148929C2910886357 @default.
- W66148929 hasConceptScore W66148929C3018697912 @default.
- W66148929 hasConceptScore W66148929C54173615 @default.
- W66148929 hasConceptScore W66148929C55493867 @default.
- W66148929 hasConceptScore W66148929C71924100 @default.
- W66148929 hasConceptScore W66148929C89560881 @default.
- W66148929 hasConceptScore W66148929C98274493 @default.
- W66148929 hasLocation W661489291 @default.
- W66148929 hasOpenAccess W66148929 @default.
- W66148929 hasPrimaryLocation W661489291 @default.
- W66148929 hasRelatedWork W1537999925 @default.
- W66148929 hasRelatedWork W1562406767 @default.
- W66148929 hasRelatedWork W2002390280 @default.
- W66148929 hasRelatedWork W2007579592 @default.
- W66148929 hasRelatedWork W2089721008 @default.
- W66148929 hasRelatedWork W2162292125 @default.
- W66148929 hasRelatedWork W2204361719 @default.
- W66148929 hasRelatedWork W2215091106 @default.
- W66148929 hasRelatedWork W2396194974 @default.
- W66148929 hasRelatedWork W66148929 @default.
- W66148929 hasVolume "9 Suppl 1" @default.
- W66148929 isParatext "false" @default.
- W66148929 isRetracted "false" @default.
- W66148929 magId "66148929" @default.
- W66148929 workType "article" @default.