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- W66223478 abstract "Mesenchymal stromal cells (MSCs) have initially been characterized as a fibroblastlike cell population that can be expanded readily in vitro, and is able to support hematopoiesis in vitro and in vivo. By serendipity it was discovered that MSCs can also be administered into the bloodstream. This mode of application formed a major breakthrough in the clinical use of MSCs, because MSC transplantation was found to cure severe immune hyperactivation states such as graft-versus-host disease after allogeneic bone marrow transplantation, or bacterial sepsis. However, MSCs were found difficult to trace and consensus to date is lacking in the scientific community as to where transplanted MSCs end up in the body and which major principles are responsible for the therapeutic effects of MSCs. This chapter gives an overview of the current knowledge on interactions of freshly transplanted MSCs with the cells in the blood stream and the vessel wall, with major organs such as lung, liver, gut, and spleen, and discusses the limitations of the methodologies used to trace transplanted MSCs. The findings will be put into perspective on how therapeutically applied, culture-expanded MSCs may exert beneficial effects." @default.
- W66223478 created "2016-06-24" @default.
- W66223478 creator A5005077808 @default.
- W66223478 creator A5066818291 @default.
- W66223478 date "2012-01-01" @default.
- W66223478 modified "2023-09-28" @default.
- W66223478 title "Fate of Intravenously Injected Mesenchymal Stem Cells and Significance for Clinical Application" @default.
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- W66223478 doi "https://doi.org/10.1007/10_2012_155" @default.
- W66223478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23334265" @default.
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