FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W66255423> ?p ?o ?g. }

• W66255423 endingPage "316" @default.
• W66255423 startingPage "307" @default.
• W66255423 abstract "IL-2 was originally isolated as a soluble factor with the property of enhancing T-lymphocyte proliferation in studies of the human immunodeficiency virus (1). The earliest studies of its activity in the cellular therapy of cancer used partially-purified IL-2 from the Jurkat human T-cell line. Subsequent studies used recombinant IL-2 produced in E. coli, an unlimited source of this valuable cytokine that has been used more than any other immunologic agent for laboratory and clinical investigations of immunotherapy for malignant and nonmalignant disease. Proof of concept for the potent activity of IL-2-activated killer cells (termed lymphokine-activated killer, or LAK cells) against established malignancy in animal models was provided in the extensive series of reports from Rosenberg and the Surgery Branch of the National Cancer Institute beginning in the mid-1980s (2–4). The earliest human studies used Jurkat-derived IL-2 and ex vivo-activated autologous LAK cells derived from leukapheresis of patients with advanced cancer. These patients initially received intravenous IL-2 before mononuclear cell collections and then received additional IL-2 following the re-infusion of autologous lymphocytes that had undergone further exposure to IL-2 ex vivo for several days. The encouraging level of activity against renal cancer and melanoma, including a 5–7% rate of durable complete remission, was particularly gratifying in light of the marked resistance of these two malignancies to chemotherapy and other biologic agents such as interferon. Subsequent clinical trials demonstrated that ex vivo exposure of patient cells to IL-2 was not necessary, as the in vivo exposure appeared to be associated with a comparable likelihood of antitumor response (5).At the same time, the success of this approach at centers outside of the National Cancer Institute was confirmed with a series of studies by the Cytokine Working Group and other institutions (6–9)." @default.
• W66255423 created "2016-06-24" @default.
• W66255423 creator A5034792001 @default.
• W66255423 creator A5084347950 @default.
• W66255423 date "2007-01-01" @default.
• W66255423 modified "2023-09-26" @default.
• W66255423 title "Interleukin-2 and Cancer Therapy" @default.
• W66255423 cites W1576327927 @default.
• W66255423 cites W1894837930 @default.
• W66255423 cites W1903698043 @default.
• W66255423 cites W1932456479 @default.
• W66255423 cites W1935218883 @default.
• W66255423 cites W1939353013 @default.
• W66255423 cites W1950572133 @default.
• W66255423 cites W1964032970 @default.
• W66255423 cites W1966320652 @default.
• W66255423 cites W1975568557 @default.
• W66255423 cites W1976079751 @default.
• W66255423 cites W1976190556 @default.
• W66255423 cites W1977597055 @default.
• W66255423 cites W1981288213 @default.
• W66255423 cites W1983806918 @default.
• W66255423 cites W1985981664 @default.
• W66255423 cites W1986634084 @default.
• W66255423 cites W1992880129 @default.
• W66255423 cites W1993051112 @default.
• W66255423 cites W1994229890 @default.
• W66255423 cites W2013014620 @default.
• W66255423 cites W2028650739 @default.
• W66255423 cites W2034128150 @default.
• W66255423 cites W2035069582 @default.
• W66255423 cites W2036840935 @default.
• W66255423 cites W2042748313 @default.
• W66255423 cites W2046584561 @default.
• W66255423 cites W2064932721 @default.
• W66255423 cites W2074068392 @default.
• W66255423 cites W2082888406 @default.
• W66255423 cites W2085925464 @default.
• W66255423 cites W2098136315 @default.
• W66255423 cites W2123914905 @default.
• W66255423 cites W2133157945 @default.
• W66255423 cites W2133988080 @default.
• W66255423 cites W2149724818 @default.
• W66255423 cites W2151246207 @default.
• W66255423 cites W2178727026 @default.
• W66255423 cites W2222964685 @default.
• W66255423 cites W2223317700 @default.
• W66255423 cites W2227568616 @default.
• W66255423 cites W2269150581 @default.
• W66255423 cites W2270408419 @default.
• W66255423 cites W2294866259 @default.
• W66255423 cites W2322553446 @default.
• W66255423 cites W2334694951 @default.
• W66255423 cites W2336865510 @default.
• W66255423 cites W3160205703 @default.
• W66255423 cites W4230274068 @default.
• W66255423 doi "https://doi.org/10.1007/978-1-59745-455-1_17" @default.
• W66255423 hasPublicationYear "2007" @default.
• W66255423 type Work @default.
• W66255423 sameAs 66255423 @default.
• W66255423 citedByCount "1" @default.
• W66255423 crossrefType "book-chapter" @default.
• W66255423 hasAuthorship W66255423A5034792001 @default.
• W66255423 hasAuthorship W66255423A5084347950 @default.
• W66255423 hasConcept C10205521 @default.
• W66255423 hasConcept C121608353 @default.
• W66255423 hasConcept C126322002 @default.
• W66255423 hasConcept C129374314 @default.
• W66255423 hasConcept C150903083 @default.
• W66255423 hasConcept C179464577 @default.
• W66255423 hasConcept C203014093 @default.
• W66255423 hasConcept C207001950 @default.
• W66255423 hasConcept C26291073 @default.
• W66255423 hasConcept C2776090121 @default.
• W66255423 hasConcept C2777371288 @default.
• W66255423 hasConcept C2777371436 @default.
• W66255423 hasConcept C2777701055 @default.
• W66255423 hasConcept C2778690821 @default.
• W66255423 hasConcept C2780674031 @default.
• W66255423 hasConcept C28328180 @default.
• W66255423 hasConcept C28651165 @default.
• W66255423 hasConcept C49382859 @default.
• W66255423 hasConcept C502942594 @default.
• W66255423 hasConcept C54355233 @default.
• W66255423 hasConcept C71924100 @default.
• W66255423 hasConcept C86803240 @default.
• W66255423 hasConcept C8891405 @default.
• W66255423 hasConceptScore W66255423C10205521 @default.
• W66255423 hasConceptScore W66255423C121608353 @default.
• W66255423 hasConceptScore W66255423C126322002 @default.
• W66255423 hasConceptScore W66255423C129374314 @default.
• W66255423 hasConceptScore W66255423C150903083 @default.
• W66255423 hasConceptScore W66255423C179464577 @default.
• W66255423 hasConceptScore W66255423C203014093 @default.
• W66255423 hasConceptScore W66255423C207001950 @default.
• W66255423 hasConceptScore W66255423C26291073 @default.
• W66255423 hasConceptScore W66255423C2776090121 @default.
• W66255423 hasConceptScore W66255423C2777371288 @default.

• next