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- W66260054 abstract "The cyclin-dependent kinases (CDKs) are essential for cell-cycle progression. Cyclins and CDK inhibitors regulate the activity of CDKs, and, in turn, the proteasome regulates these proteins. Destruction of proteins that prevent transition into anaphase or S phase is controlled by two dedicated multiprotein complexes, the anaphase-promoting complex (APC) and Skp1-cullin-F-box protein ligase complex. These gatekeepers include ubiquitin E3 ligases that specify the proteins that will be targeted for degradation by the proteasome. Proteasome activity is required for progression through the cell cycle; and when proteasome activity is disrupted by any of a number of small molecule inhibitors, cell cycle arrest follows. The presence or absence of p53 affects proteasome inhibitorinduced cell cycle arrest: in p53+ cells, proteasome inhibitors cause arrest at the G1/S boundary, while proteasome inhibition in p53- cells leads to G2/M phase arrest. In some instances, proteasome inhibition also culminates in the cell death; however, proteasome inhibitor-induced apoptosis may be a consequence of effects on pathways not directly involved in cell-cycle progression, and may also be dependent on the specific proteasome inhibitor or cell line." @default.
- W66260054 created "2016-06-24" @default.
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- W66260054 date "2004-01-01" @default.
- W66260054 modified "2023-09-26" @default.
- W66260054 title "The Proteasome in Cell-Cycle Regulation" @default.
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- W66260054 doi "https://doi.org/10.1007/978-1-59259-794-9_6" @default.
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