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- W66366820 abstract "Introduction Transcatheter Aortic Valve Implantation (TAVI) for patients with severe aortic stenosis at unacceptably high surgical risk has been shown to improve survival compared to medical therapy. Our aim was for the first time to use the ‘reference standard’ technique, Cardiovascular Magnetic Resonance (CMR) to accurately demonstrate serial changes in left ventricular (LV) function and mass post TAVI compared to surgical aortic valve replacement (SAVR). Methods Forty patients (20 TAVI, 20 SAVR) completed baseline and 6 month follow-up 1.5T CMR scans. Patient characteristics were matched for gender (male 10 vs 15, p=0.1) and BMI (27 ±3 vs 27 ±4, p=0.88) but due to TAVI selection criteria not for age (80 ±7 vs 75 ±7, p=0.01) or EuroSCORE (20 ±11 vs 6.7 ±3, p Results TAVI resulted in a significant reduction in LV end-systolic volume (ESV) and mass and an increase in ejection fraction (EF). Post SAVR LV end-diastolic volume (EDV), ESV and mass significantly reduced with no significant change in EF (Table 1). EDV was significantly lower (p=0.03) in the SAVR group at 6 months when compared to TAVI. Multivariate analysis identified diabetes as an independent predictor of poor LV mass regression (B 7.6, p=0.02). Gender, CAD, Renal failure and AF had no association to remodelling when controlled for baseline parameters. In SAVR, CABG was associated with higher EDV and stroke volume at 6 months (B 11.7, p= Conclusion In high risk patients, TAVI resulted in comparable levels of LV reverse remodelling to lower risk SAVR patients. TAVI significantly improved LV ESV, mass and EF at 6 months. No specific variable predicted reverse remodelling although LV mass reduction was less pronounced in diabetic patients. These changes in ventricular remodelling may be responsible for the reported improved prognosis post TAVI." @default.
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- W66366820 date "2011-11-22" @default.
- W66366820 modified "2023-09-26" @default.
- W66366820 title "Abstract 14939: Reverse Left Ventricular remodelling 6 months post-Transcatheter Aortic Valve Implantation compared to Surgical Aortic Valve Replacement. A Cardiovascular Magnetic Resonance Study." @default.
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