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• W66543921 abstract "Although the effect of the nervous system upon the cardiovascular system has been known for a long while, the clinical association in the Western literature between electrocardiographic abnormalities and central nervous system disease goes back only thirty-five years when Byer, Ashman and Toth (1) reported five patients (four with strokes and one with hypertensive encephalopathy) with large upright T waves and long Q-T intervals. In 1953, Levine reported (2) a patient with subarachnoid hemorrhage whose electrocardiogram showed an apparent myocardial infarction. The heart was said to be normal at autopsy. Levine felt that the abnormalities were due to vagal stimulation and referred to Fulton’s work (3) which suggested that areas in the orbital frontal cortex were the major cortical representations of the vagus nerve. Burch and his colleagues (4) drew attention to peaked T waves, long Q-T intervals and U waves as manifestations of central nervous system disease, primarily but not exclusively, in subarachnoid hemorrhage patients. It is from this paper that the popular term “cerebral T waves” probably arose. Since that time a large number of cases of so-called neurogenic electrocardiographic changes have been reported in the world’s literature. Despite the large number of case reports (not enumerated here) little is known about the mechanism of these changes. Some studies have shown post mortem evidence of myocardial damage while others have failed to show such histologic lesions." @default.
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• W66543921 date "1985-01-01" @default.
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• W66543921 title "Electrocardiographic Manifestations of Neurological Disease: A Unifying Hypothesis" @default.
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• W66543921 doi "https://doi.org/10.1007/978-1-4613-2587-1_12" @default.
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