Matches in SemOpenAlex for { <https://semopenalex.org/work/W66624537> ?p ?o ?g. }
- W66624537 endingPage "311" @default.
- W66624537 startingPage "311" @default.
- W66624537 abstract "Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide, accounting for over half a million deaths per year. The geographic pattern of HCC incidence is parallel to exposure to viral etiologic factors. Its incidence is increasing, ranging between 3% and 9% annually depending on the geographical location, and variability in the incidence rates correspond closely to the prevalence and pattern of the primary etiologic factors. Chronic infections with hepatitis B viruses or hepatitis C viruses have both been recognized as human liver carcinogens with a combined attributable fraction of at least 75% of all HCC cases. Multiple non-viral factors have been implicated in the development of HCC. Increased body mass index and diabetes with subsequent development of non-alcoholic steatohepatitis represent significant risk factors for HCC. Other non-viral causes of HCC include iron overload syndromes, alcohol use, tobacco, oral contraceptive, aflatoxin, pesticides exposure and betel quid chewing, a prevalent habit in the developing world. Wilson disease, α-1 antitrypsin deficiency, Porphyrias, autoimmune hepatitis, Schistosoma japonicum associated with positive hepatitis B surface antigen, and thorotrast-ray are also contributing hepatocellualar carcinoma. In addition, primary biliary cirrhosis, congestive liver disease and family history of liver cancer increase the risk of HCC incident. In conclusion, clarification of relevant non-viral causes of HCC will help to focus clinicians on those risk factors that are modifiable. The multilevel preventative approach will hopefully lead to a reduction in incidence of non-viral HCC, and a decrease in the patient morbidity and mortality as well as the societal economic burden associated with HCC." @default.
- W66624537 created "2016-06-24" @default.
- W66624537 creator A5003416668 @default.
- W66624537 creator A5004010356 @default.
- W66624537 date "2013-01-01" @default.
- W66624537 modified "2023-10-18" @default.
- W66624537 title "Non-viral factors contributing to hepatocellular carcinoma" @default.
- W66624537 cites W1522687886 @default.
- W66624537 cites W1965581610 @default.
- W66624537 cites W1966160579 @default.
- W66624537 cites W1966435408 @default.
- W66624537 cites W1967392315 @default.
- W66624537 cites W1973210473 @default.
- W66624537 cites W1973368924 @default.
- W66624537 cites W1975813643 @default.
- W66624537 cites W1977489168 @default.
- W66624537 cites W1980755680 @default.
- W66624537 cites W1980950685 @default.
- W66624537 cites W1981293590 @default.
- W66624537 cites W1982307785 @default.
- W66624537 cites W1983292214 @default.
- W66624537 cites W1984061101 @default.
- W66624537 cites W1988051941 @default.
- W66624537 cites W1988193050 @default.
- W66624537 cites W1988208946 @default.
- W66624537 cites W1995966228 @default.
- W66624537 cites W1999577642 @default.
- W66624537 cites W2001393463 @default.
- W66624537 cites W2001837599 @default.
- W66624537 cites W2001869632 @default.
- W66624537 cites W2002605005 @default.
- W66624537 cites W2003052841 @default.
- W66624537 cites W2007242843 @default.
- W66624537 cites W2008179596 @default.
- W66624537 cites W2009279912 @default.
- W66624537 cites W2010136841 @default.
- W66624537 cites W2011791532 @default.
- W66624537 cites W2017207954 @default.
- W66624537 cites W2020830322 @default.
- W66624537 cites W2027014617 @default.
- W66624537 cites W2027157112 @default.
- W66624537 cites W2029776483 @default.
- W66624537 cites W2030682199 @default.
- W66624537 cites W2034349902 @default.
- W66624537 cites W2036908350 @default.
- W66624537 cites W2040510760 @default.
- W66624537 cites W2042165138 @default.
- W66624537 cites W2044473960 @default.
- W66624537 cites W2046719161 @default.
- W66624537 cites W2048652058 @default.
- W66624537 cites W2049032735 @default.
- W66624537 cites W2059616586 @default.
- W66624537 cites W2059861068 @default.
- W66624537 cites W2062929727 @default.
- W66624537 cites W2063321450 @default.
- W66624537 cites W2064057901 @default.
- W66624537 cites W2065788317 @default.
- W66624537 cites W2070141763 @default.
- W66624537 cites W2073436773 @default.
- W66624537 cites W2073595067 @default.
- W66624537 cites W2074705008 @default.
- W66624537 cites W2075990372 @default.
- W66624537 cites W2076684001 @default.
- W66624537 cites W2077071754 @default.
- W66624537 cites W2077955753 @default.
- W66624537 cites W2079636538 @default.
- W66624537 cites W2084180808 @default.
- W66624537 cites W2088277031 @default.
- W66624537 cites W2097985419 @default.
- W66624537 cites W2099865291 @default.
- W66624537 cites W2104138862 @default.
- W66624537 cites W2105271269 @default.
- W66624537 cites W2110758352 @default.
- W66624537 cites W2115161881 @default.
- W66624537 cites W2120215326 @default.
- W66624537 cites W2120970673 @default.
- W66624537 cites W2128339763 @default.
- W66624537 cites W2131965674 @default.
- W66624537 cites W2137052325 @default.
- W66624537 cites W2141662760 @default.
- W66624537 cites W2142137274 @default.
- W66624537 cites W2143502485 @default.
- W66624537 cites W2146827253 @default.
- W66624537 cites W2149293425 @default.
- W66624537 cites W2153470367 @default.
- W66624537 cites W2154239359 @default.
- W66624537 cites W2155687118 @default.
- W66624537 cites W2158965278 @default.
- W66624537 cites W2161377376 @default.
- W66624537 cites W2165484785 @default.
- W66624537 cites W2165680505 @default.
- W66624537 cites W2165778365 @default.
- W66624537 cites W2167004267 @default.
- W66624537 cites W2171558918 @default.
- W66624537 cites W2321119966 @default.
- W66624537 cites W2328992604 @default.
- W66624537 cites W2401389184 @default.
- W66624537 cites W2513967314 @default.