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- W66647953 abstract "This chapter discusses long-term toxicity after cisplatinum-based chemotherapy. Pulmonary complications of bleomycin containing chemotherapy regimens are well-known and feared. In many of the early reports on PVB treated patients, pulmonary complications were reported in 5–10% of cases including fatal complications in 1–2%. The pulmonary toxicities related to the cumulative dose of bleomycin, that is, pulmonary problems, are relatively seldom encountered at doses <300 IU of bleomycin. Occasional patients do, however, encounter pulmonary toxicity at much lower doses, which has made it mandatory to monitor pulmonary function even at low total doses and to reduce or omit bleomycin if subclinical effects are shown. The use of alkylating agents for the treatment of malignant diseases such as Hodgkin's disease is now known to increase the risk of leukaemia. Besides the few patients with primary mediastinal germ cell tumors, any connection between the occurrence or treatment of germ cell tumors and secondary leukaemia has been restricted to the well-described late effect of radiotherapy." @default.
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- W66647953 title "Long-Term Toxicity after Cisplatinum-Based Chemotherapy" @default.
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- W66647953 doi "https://doi.org/10.1016/b978-0-08-042198-8.50087-x" @default.
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