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- W66730756 abstract "It is well known that folate is essential for fetal brain development, but the effect of folate on maternal brain is unknown. Myelin basic protein (MBP), a major structural protein of myelin, is thought to be important for the maintenance of myelin in the central nervous system (CNS). The synthesis of MBP requires a universal methyl donor, S-adenosylmethionine, whose synthesis is dependent on folate and its involvement in one-carbon metabolism. We investigated the effects of folic acid on the expression of MBP in the maternal CNS during pregnancy and lactation period. Female Sprague-Dawley rats were fed either folic acid sufficient (8mg/kg diet) or deficient (0mg/kg diet) diet from 2 weeks prior to the mating throughout the entire pregnancy and lactation period. The MBP expression in the cortex, hippocampus and spinal cord was observed by immunohistochemical study and western blot analysis. At gestational day 20, the MBP expression in the spinal cord was increased in both groups, but the increase was greater in animals on a folic acid sufficient diet than those on a deficient diet. In conclusion, the maternal folic acid deficiency might inhibit the MBP synthesis in the spinal cord during pregnancy, and this might affect the maternal neurological function. This work was supported by the second stage of Brain Korea 21 project in 2007" @default.
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- W66730756 date "2008-03-01" @default.
- W66730756 modified "2023-09-25" @default.
- W66730756 title "Effects of folic acid on the myelin basic protein expression in the maternal brain" @default.
- W66730756 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1104.5" @default.
- W66730756 hasPublicationYear "2008" @default.
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