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- W66758872 abstract "Adipocyte differentiation is a key process in the development of obesity as well as in normal development and function of adipose tissue. We have previously shown that Rhodiola extract high in phenolics dose-dependently inhibited the enzyme activity of both glucose-6-phosphate dehydrogenase (G6PDH), the rate-limiting enzyme of the pentose phosphate pathway (PPP), and proline dehydrogenase (PDH) in differentiating 3T3-L1 preadipocytes. The present study is designed to investigate whether the inhibitory effects of Rhodiola extract on enzyme activities correlate with gene expression pattern and further PPARγ mRNA and protein expression, a key adipogenic transcription factor, by semi-quantitative RT-PCR and Western blot analysis. 3T3-L1 preadipocytes were treated with various concentrations of Rhodiola extract for up to 8 days following standard induction of differentiation. Rhodiola treatment significantly inhibited expression of G6PDH and PDH mRNAs as well as mRNA and protein expression in a dose-dependent manner. These results indicate that Rhodiola extract can inhibit adipogenesis through a mechanism(s) that involves direct downregulation of PPARγ gene expression or via modulation of pentose phosphate pathway linked to PDH, which may be important for cellular energy and redox environment in adipocytes." @default.
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- W66758872 date "2008-03-01" @default.
- W66758872 modified "2023-09-23" @default.
- W66758872 title "Rhodiola extract inhibits adipocyte differentiation in 3T3‐L1 cells" @default.
- W66758872 doi "https://doi.org/10.1096/fasebj.22.1_supplement.148.6" @default.
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