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- W66772694 abstract "This chapter provides an overview of our current knowledge of the physiology and pathophysiology of ion channels on myelinated axons as they relate to demyelinating diseases. This chapter discusses three major classes of ion channels on axons of mammalian myelinated fibers and their roles in normal axons and pathological axons in multiple sclerosis (MS). These axonal ion channels Na, K, and Ca are potential targets in therapeutic treatment of multiple sclerosis. Deficiency of Na channel in the internodes contributes to conduction block, their plasticity in gene expression contributes to abnormal firing patterns in MS, and their linkage to Ca homeostasis might contribute to Ca-mediated axonal injury. Next, coming to the K channels, most of which are sealed by myelin in a normal nerve, has best functional analysis carried out for the juxtaparanodal Kv1.1. The Ca channels may translate nerve activity into graded axonal Ca elevation that can drive various processes including axonal elongation and axonal transport. Pharmacological manipulation of these three channels can produce short-term neurological effects and changes in glial-axon relationship that might be beneficiary for long-term functional restoration" @default.
- W66772694 created "2016-06-24" @default.
- W66772694 creator A5060174001 @default.
- W66772694 date "2005-01-01" @default.
- W66772694 modified "2023-09-27" @default.
- W66772694 title "The Roles of Potassium and Calcium Channels in Physiology and Pathophysiology of Axons" @default.
- W66772694 cites W1505719764 @default.
- W66772694 cites W1531524726 @default.
- W66772694 cites W1571824892 @default.
- W66772694 cites W1640985392 @default.
- W66772694 cites W1674100775 @default.
- W66772694 cites W1678527168 @default.
- W66772694 cites W1813275637 @default.
- W66772694 cites W1830560196 @default.
- W66772694 cites W1833609357 @default.
- W66772694 cites W1869285569 @default.
- W66772694 cites W1964014944 @default.
- W66772694 cites W1967839934 @default.
- W66772694 cites W1970895150 @default.
- W66772694 cites W1971017725 @default.
- W66772694 cites W1971089744 @default.
- W66772694 cites W1979316328 @default.
- W66772694 cites W1984175906 @default.
- W66772694 cites W1985808169 @default.
- W66772694 cites W1985940938 @default.
- W66772694 cites W1988120560 @default.
- W66772694 cites W1991138408 @default.
- W66772694 cites W1993637697 @default.
- W66772694 cites W1994805414 @default.
- W66772694 cites W1995060299 @default.
- W66772694 cites W1997105777 @default.
- W66772694 cites W2009074935 @default.
- W66772694 cites W2011469898 @default.
- W66772694 cites W2013425296 @default.
- W66772694 cites W2017263107 @default.
- W66772694 cites W2018764168 @default.
- W66772694 cites W2019547077 @default.
- W66772694 cites W2021706887 @default.
- W66772694 cites W2033060818 @default.
- W66772694 cites W2033195419 @default.
- W66772694 cites W2034132958 @default.
- W66772694 cites W2036313263 @default.
- W66772694 cites W2038894306 @default.
- W66772694 cites W2045554245 @default.
- W66772694 cites W2046213059 @default.
- W66772694 cites W2058706580 @default.
- W66772694 cites W2063741079 @default.
- W66772694 cites W2063963676 @default.
- W66772694 cites W2064768860 @default.
- W66772694 cites W2065263158 @default.
- W66772694 cites W2065857917 @default.
- W66772694 cites W2068895477 @default.
- W66772694 cites W2072381786 @default.
- W66772694 cites W2079735011 @default.
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- W66772694 cites W2087703473 @default.
- W66772694 cites W2089146682 @default.
- W66772694 cites W2094390230 @default.
- W66772694 cites W2095000653 @default.
- W66772694 cites W2105994616 @default.
- W66772694 cites W2106670341 @default.
- W66772694 cites W2112169774 @default.
- W66772694 cites W2114230130 @default.
- W66772694 cites W2115806568 @default.
- W66772694 cites W2121399400 @default.
- W66772694 cites W2122971055 @default.
- W66772694 cites W2132210863 @default.
- W66772694 cites W2143144699 @default.
- W66772694 cites W2143477348 @default.
- W66772694 cites W2145692459 @default.
- W66772694 cites W2146582067 @default.
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- W66772694 cites W2155979828 @default.
- W66772694 cites W2157788198 @default.
- W66772694 cites W2164584173 @default.
- W66772694 cites W2168506147 @default.
- W66772694 cites W2175956536 @default.
- W66772694 cites W2249636885 @default.
- W66772694 cites W2272959763 @default.
- W66772694 cites W2273764020 @default.
- W66772694 cites W2334219285 @default.
- W66772694 cites W4238542215 @default.
- W66772694 cites W4296759751 @default.
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- W66772694 doi "https://doi.org/10.1016/b978-012738761-1/50006-7" @default.
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