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• W66951290 abstract "Research Article1 October 1992free access Sharp anterior boundary of homeotic gene expression conferred by the fushi tarazu protein. J. Müller J. Müller Zoological Institute, University of Zürich, Switzerland. Search for more papers by this author M. Bienz M. Bienz Zoological Institute, University of Zürich, Switzerland. Search for more papers by this author J. Müller J. Müller Zoological Institute, University of Zürich, Switzerland. Search for more papers by this author M. Bienz M. Bienz Zoological Institute, University of Zürich, Switzerland. Search for more papers by this author Author Information J. Müller1 and M. Bienz1 1Zoological Institute, University of Zürich, Switzerland. The EMBO Journal (1992)11:3653-3661https://doi.org/10.1002/j.1460-2075.1992.tb05450.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Parasegmental boundaries in the Drosophila embryo are delimited by the products of the fushi tarazu (ftz) and even-skipped (eve) genes. We show here that these act through particular key control regions of the homeotic gene Ultrabithorax (Ubx) to generate ftz- or eve-like stripe patterns of beta-galactosidase expression. Footprint analysis and tests in transformed embryos of constructs bearing mutated footprint regions suggest that ftz protein acts directly as a transcriptional activator of Ubx. Its activity outside the Ubx expression domain is suppressed by hunchback (hb), a repressor of Ubx. Some DNA binding sites for ftz protein are adjacent to, others overlap binding sites for hb protein, and we provide evidence that ftz protein competes with hb protein for DNA binding and/or for transcriptional activation. This competition mechanism results in a sharp anterior expression boundary. Direct activation of homeotic gene control regions by ftz (or eve) protein may be a regulatory step which is generally used to align expression of homeotic genes with parasegmental boundaries. Previous ArticleNext Article Volume 11Issue 101 October 1992In this issue RelatedDetailsLoading ..." @default.
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• W66951290 date "1992-10-01" @default.
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• W66951290 title "Sharp anterior boundary of homeotic gene expression conferred by the fushi tarazu protein." @default.
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• W66951290 doi "https://doi.org/10.1002/j.1460-2075.1992.tb05450.x" @default.
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