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- W66985197 abstract "This chapter provides a comparative analysis of magnetic resonance imaging and mammography in screening for breast cancer in women with a familial or genetic predisposition. Mammography is the only screening method for breast cancer that is extensively evaluated and widely used. Because of the low sensitivity of mammography in BRCA1/2 mutation carriers and young premenopausal women with high breast density, especially for these groups there is an interest in better imaging methods. Ultrasound is evaluated in young women with dense breasts and women with a genetic risk for breast cancer. It may be more sensitive, but less specific, than mammography. In a diagnostic setting, magnetic resonance imaging (MRI) is a sensitive breast imaging modality, especially in detecting multicentric disease. The specificity is variable, ranging from 37-100%. Benign fibroadenomas and fibrocystic disease often cause false-positive MRI results. The sensitivity of MRI for ductal carcinoma in situ (DCIS) in a diagnostic setting is variable and ranges from 40-100%. Low-grade DCIS in particular is more frequently associated with slow uptake of contrast and no washout, mimicking of a benign lesion, or no contrast uptake. MRI screening presents some pitfalls compared to mammography screening such as breast MRI screening is a costly and time-consuming imaging method, requiring very experienced radiologists. MRI has relative low specificity compared to mammography and high number of probably benign findings. The possible anxiety and costs caused by these false-positive results have to be taken into account in the decision making about screening. Improvement of the MRI's specificity is very important in order to reduce unneeded additional investigations and additional costs." @default.
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- W66985197 date "2008-01-01" @default.
- W66985197 modified "2023-09-27" @default.
- W66985197 title "Screening for Breast Cancer in Women with a Familial or Genetic Predisposition" @default.
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- W66985197 doi "https://doi.org/10.1016/b978-012374212-4.50051-1" @default.
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