Matches in SemOpenAlex for { <https://semopenalex.org/work/W67087966> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W67087966 endingPage "87.35" @default.
- W67087966 startingPage "87.35" @default.
- W67087966 abstract "Abstract T cells were recently shown to support learning and memory, although the underlying mechanisms for this phenomenon are yet unknown. Here, we show that severe combined immune deficient (SCID) mice, shown to be impaired in assays of learning and memory, display a pronounced pro-inflammatory (M1) skew of meningeal myeloid cells. Acute lymphopenia induced by FTY720, a sphingosine-phosphate receptor agonist, or blockade of T cell migration into the meninges using anti-VLA4 antibodies, results in similar cognitive impairment and M1-skewed meningeal myeloid phenotype in wild type mice. The role of IL-4 is critical: we show accumulation of IL-4+ CD4+ T cells in the meninges of wild type mice after MWM training. Moreover, IL-4 knockout mice exhibit profound cognitive impairment and M1 skew. Transfer of IL-4 knockout bone marrow to wild type mice results in meningeal myeloid inflammation and impaired learning, while transfer of wild type T lymphocytes to IL-4 knockout mice is sufficient to rescue both behavioral phenotype and M1 skew. Our results point to a critical role for meningeal T cells, and for IL-4 in particular, in the regulation of meningeal myeloid cells and concomitant cognitive function. These results might lead to development of new immune-based therapies for cognitive conditions associated with immune decline, such as HIV- and age-associated dementia." @default.
- W67087966 created "2016-06-24" @default.
- W67087966 creator A5000758966 @default.
- W67087966 creator A5004751788 @default.
- W67087966 creator A5009077877 @default.
- W67087966 creator A5056713732 @default.
- W67087966 creator A5087705733 @default.
- W67087966 creator A5088728393 @default.
- W67087966 date "2010-04-01" @default.
- W67087966 modified "2023-09-24" @default.
- W67087966 title "Meningeal Immunity, Learning and Memory, and IL-4: Do T cells Make You Smart? (87.35)" @default.
- W67087966 doi "https://doi.org/10.4049/jimmunol.184.supp.87.35" @default.
- W67087966 hasPublicationYear "2010" @default.
- W67087966 type Work @default.
- W67087966 sameAs 67087966 @default.
- W67087966 citedByCount "0" @default.
- W67087966 crossrefType "journal-article" @default.
- W67087966 hasAuthorship W67087966A5000758966 @default.
- W67087966 hasAuthorship W67087966A5004751788 @default.
- W67087966 hasAuthorship W67087966A5009077877 @default.
- W67087966 hasAuthorship W67087966A5056713732 @default.
- W67087966 hasAuthorship W67087966A5087705733 @default.
- W67087966 hasAuthorship W67087966A5088728393 @default.
- W67087966 hasConcept C126322002 @default.
- W67087966 hasConcept C169760540 @default.
- W67087966 hasConcept C170493617 @default.
- W67087966 hasConcept C182704531 @default.
- W67087966 hasConcept C203014093 @default.
- W67087966 hasConcept C2776403516 @default.
- W67087966 hasConcept C2776914184 @default.
- W67087966 hasConcept C2779282312 @default.
- W67087966 hasConcept C71924100 @default.
- W67087966 hasConcept C86803240 @default.
- W67087966 hasConcept C87753298 @default.
- W67087966 hasConcept C8891405 @default.
- W67087966 hasConceptScore W67087966C126322002 @default.
- W67087966 hasConceptScore W67087966C169760540 @default.
- W67087966 hasConceptScore W67087966C170493617 @default.
- W67087966 hasConceptScore W67087966C182704531 @default.
- W67087966 hasConceptScore W67087966C203014093 @default.
- W67087966 hasConceptScore W67087966C2776403516 @default.
- W67087966 hasConceptScore W67087966C2776914184 @default.
- W67087966 hasConceptScore W67087966C2779282312 @default.
- W67087966 hasConceptScore W67087966C71924100 @default.
- W67087966 hasConceptScore W67087966C86803240 @default.
- W67087966 hasConceptScore W67087966C87753298 @default.
- W67087966 hasConceptScore W67087966C8891405 @default.
- W67087966 hasIssue "1_Supplement" @default.
- W67087966 hasLocation W670879661 @default.
- W67087966 hasOpenAccess W67087966 @default.
- W67087966 hasPrimaryLocation W670879661 @default.
- W67087966 hasRelatedWork W1919476441 @default.
- W67087966 hasRelatedWork W2040423913 @default.
- W67087966 hasRelatedWork W2052285428 @default.
- W67087966 hasRelatedWork W2289815365 @default.
- W67087966 hasRelatedWork W2946580071 @default.
- W67087966 hasRelatedWork W3162634027 @default.
- W67087966 hasRelatedWork W4280593573 @default.
- W67087966 hasRelatedWork W4283030273 @default.
- W67087966 hasRelatedWork W4363678670 @default.
- W67087966 hasRelatedWork W74538776 @default.
- W67087966 hasVolume "184" @default.
- W67087966 isParatext "false" @default.
- W67087966 isRetracted "false" @default.
- W67087966 magId "67087966" @default.
- W67087966 workType "article" @default.