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- W67143114 abstract "This chapter introduces genetic and biochemical mechanisms that are implicated in the development of the renal epithelia. As with any scientific endeavor, there is some controversy and conflicting data regarding potential mechanisms that regulate early nephron formation. This chapter attempts to relate recent insights that are gained primarily from the phenotypic analysis of mutant mice with more classical in vitro and biochemical data regarding induction and differentiation. To put these factors into a morphological context, a brief description of the process of mesenchyme-to-epithelial conversion is presented in the chapter. The metanephric mesenchyme lineage is fixed within the environment of the intermediate mesoderm. Several key factors are now known to mark this as the renal anlagen and are required for epithelial specification. The signals that induce the mesenchyme to become epithelium are also being elucidated. The chapter discusses factors that promote growth, remodeling, and cell-type specification of the nephron segments. The trio of secreted signaling molecules bFGF, TGF-α, and LIF has also been implicated as a mesenchymal inducer, although genetic evidence supporting their in vivo role is lacking." @default.
- W67143114 created "2016-06-24" @default.
- W67143114 creator A5049709224 @default.
- W67143114 creator A5076789742 @default.
- W67143114 date "2003-01-01" @default.
- W67143114 modified "2023-09-23" @default.
- W67143114 title "Formation and Development of Nephrons" @default.
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- W67143114 doi "https://doi.org/10.1016/b978-012722441-1/50016-6" @default.
- W67143114 hasPublicationYear "2003" @default.
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