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• W67204842 abstract "Both serum creatinine and measuring GFR can be used to evaluate renal function in dogs suspected to have chronic kidney disease (CKD). Although high creatinine levels usually indicate renal disease, normal creatinine levels can be present in dogs with decreased renal filtration. Measuring GFR is generally believed to be the most accurate way of detecting decreased renal filtration and scintigraphy GFR using 99mTc-DTPA has been found to correlate well with the ‘gold standard’ inulin clearance method.When measuring GFR by scintigraphy, 99mTc-DTPA is injected intravenously and radioactive decay of technetium gives rise to gamma radiation, which is registered by a gamma camera. Pictures and curves of radioactivity in the kidneys are generated by means of a computer program. Calculation of GFR can be performed by two methods; by the integral method, where GFR is presented as ml/kg/min and the plasma method, where GFR is presented as ml/L/min.In this study, the GFR measured by scintigraphy was compared with the serum creatinine concentration in 23 dogs with suspected CKD. GFR was calculated with integral and plasma methods by a radiologist and a veterinary student.The results confirmed that a normal creatinine value does not necessarily indicate normal filtration by the kidneys. In addition, the study illustrated that dogs with moderate to severe decreased kidney function could have a normal concentration of serum creatinine and that the creatinine value among these dogs showed no tendency of being high within the reference value. The study also showed the advantage of measuring one kidney’s function at a time, which is possible only by GFR scintigraphy. SAMMANFATTNINGVid misstanke om kronisk njursjukdom pa hund kan bade kreatininkoncentration i serum och GFR matas. Ett kreatininvarde som overstiger det ovre referensvardet tyder vanligen pa en nedsatt njurfunktion, men hos hundar med nedsatt filtration kan aven en normal kreatininkoncentration ses. Matning av njurarnas glomerulara filtrationshastighet (GFR) anses vara den basta metoden for kontroll av njurfunktionen hos hund och matning av GFR genom scintigrafi med 99mTc-DTPA har visat sig korrelera val med ’the gold standard method’ for GFR-matning; renal clearance av inulin. Vid matning av GFR genom scintigrafi injiceras 99mTc-DTPA intravenost i hunden. Genom radioaktivt sonderfall av 99mTc uppstar gammastralar som fangas upp med en gammakamera. Via ett dataprogram erhalls bilder och kurvor som visar njurens upptag av radioaktivitet. For berakning av GFR anvands tva olika metoder; integralmetoden, dar GFR-varden erhalls i ml/kg/min och plasmametoden, dar GFR-varden erhalls i ml/L/min. I den har studien jamfordes GFR-varden erhallna fran scintigrafi med kreatininvarden i serum hos 23 hundar med misstankt kronisk njursjukdom. GFR beraknades med bade integral- och plasmametoden av en radiolog och en veterinarstudent. Resultaten bekraftade att ett normalt kreatininvarde i serum inte behover betyda att njurfiltrationen ar normal. Dessutom noterades att hundar med mattligt till kraftigt nedsatt njurfiltration kan ha normalt kreatininvarde i serum. Det sags ingen tendens till att kreatininvardet hos dessa hundar lag i det ovre referensomradet. Studien visade ocksa fordelen med att kunna studera funktionen i vardera njuren for sig – nagot som ar mojligt endast med scintigrafi." @default.
• W67204842 created "2016-06-24" @default.
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• W67204842 date "2010-01-28" @default.
• W67204842 modified "2023-09-27" @default.
• W67204842 title "En jämförande studie mellan kreatininkoncentration i serum och GFR mätt med scintigrafi hos hund med misstänkt kronisk njursjukdom" @default.
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