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- W67312085 abstract "Publisher SummaryThe first major immunological requirement for vaccines to be effective earlier in life is that it should be able to induce stronger and faster antibody responses than those elicited by current infant vaccines. These limitations apparently result from interactions between suboptimal antigen presenting cells (APC) and T-cells rather than from intrinsic T-cell defects. The optimal immunogenicity–reactogenicity balance of the new vaccine formulations will have to be carefully defined in young populations. They call for specific ethical and regulatory considerations. Strategies for early-life immunization may rely on an early priming of neonatal B cells irrespective of whether antibody responses develop, followed by boosting at a later age with a vaccine formulation that enhances antibody responses. Early-primed T and B cells may both enhance subsequent responses and/or directly contribute to protection, even under conditions in which maternal immunity limits vaccine antibody responses." @default.
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- W67312085 date "2003-01-01" @default.
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- W67312085 title "IMMUNOLOGY" @default.
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- W67312085 doi "https://doi.org/10.1016/b978-012107258-2/50007-x" @default.
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