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- W6733712 abstract "The Omega class of cytosolic glutathione transferases was initially recognized by bioinformatic analysis of human sequence databases, and orthologous sequences were subsequently discovered in mouse, rat, pig, Caenorhabditis elegans, Schistosoma mansoni, and Drosophila melanogaster. In humans and mice, two GSTO genes have been recognized and their genetic structures and expression patterns identified. In both species, GSTO1 mRNA is expressed in liver and heart as well as a range of other tissues. GSTO2 is expressed predominantly in the testis, although moderate levels of expression are seen in other tissues. Extensive immunohistochemistry of rat and human tissue sections has demonstrated cellular and subcellular specificity in the expression of GSTO1‐1. The crystal structure of recombinant human GSTO1‐1 has been determined, and it adopts the canonical GST fold. A cysteine residue in place of the catalytic tyrosine or serine residues found in other GSTs was shown to form a mixed disulfide with glutathione. Omega class GSTs have dehydroascorbate reductase and thioltransferase activities and also catalyze the reduction of monomethylarsonate, an intermediate in the pathway of arsenic biotransformation. Other diverse actions of human GSTO1‐1 include modulation of ryanodine receptors and interaction with cytokine release inhibitory drugs. In addition, GSTO1 has been linked to the age at onset of both Alzheimer's and Parkinson's diseases. Several polymorphisms have been identified in the coding regions of the human GSTO1 and GSTO2 genes. Our laboratory has expressed recombinant human GSTO1‐1 and GSTO2‐2 proteins, as well as a number of polymorphic variants. The expression and purification of these proteins and determination of their enzymatic activity is described." @default.
- W6733712 created "2016-06-24" @default.
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- W6733712 date "2005-01-01" @default.
- W6733712 modified "2023-10-13" @default.
- W6733712 title "Characterization of the Omega Class of Glutathione Transferases" @default.
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- W6733712 cites W1584447315 @default.
- W6733712 cites W1773516573 @default.
- W6733712 cites W1847176884 @default.
- W6733712 cites W1964941174 @default.
- W6733712 cites W1969120823 @default.
- W6733712 cites W1969419384 @default.
- W6733712 cites W1970242970 @default.
- W6733712 cites W1970831257 @default.
- W6733712 cites W1973706463 @default.
- W6733712 cites W1975353423 @default.
- W6733712 cites W1976690731 @default.
- W6733712 cites W1982473305 @default.
- W6733712 cites W1987878551 @default.
- W6733712 cites W1990994253 @default.
- W6733712 cites W2000025661 @default.
- W6733712 cites W2001672954 @default.
- W6733712 cites W2006012417 @default.
- W6733712 cites W2020167031 @default.
- W6733712 cites W2031652215 @default.
- W6733712 cites W2034036432 @default.
- W6733712 cites W2037102375 @default.
- W6733712 cites W2040606164 @default.
- W6733712 cites W2043445250 @default.
- W6733712 cites W2046265661 @default.
- W6733712 cites W2046855853 @default.
- W6733712 cites W2047687145 @default.
- W6733712 cites W2048199914 @default.
- W6733712 cites W2052548407 @default.
- W6733712 cites W2053540502 @default.
- W6733712 cites W2055429017 @default.
- W6733712 cites W2057029503 @default.
- W6733712 cites W2060187730 @default.
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- W6733712 cites W2084314209 @default.
- W6733712 cites W2085249706 @default.
- W6733712 cites W2087050793 @default.
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- W6733712 doi "https://doi.org/10.1016/s0076-6879(05)01005-0" @default.
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