Matches in SemOpenAlex for { <https://semopenalex.org/work/W67345071> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W67345071 endingPage "6" @default.
- W67345071 startingPage "1002" @default.
- W67345071 abstract "Carvacrol and thymol are phenolic compounds with similar structures isolated from many aromatic plants, and have been demonstrated to exert multiple pharmacological effects. The metabolic and pharmacokinetic behaviour of thymol and carvacrol has received much attention. Carvacrol and thymol have been demonstrated to undergo phase I metabolism such as hydroxylation reaction. However, drug-metabolizing enzymes involved in this process remain unclear. Given that cytochrome P450s (CYPs) are involved in most phase I metabolism, the aim of the present study was to investigate the role of CYPs in the metabolism of thymol and carvacrol. After incubation with human liver microsomes (HLMs) in the presence of NADPH, a new metabolite and two metabolites were detected for thymol and carvacrol, respectively. A combination of chemical inhibition studies and assays with recombinant CYP isoforms demonstrated that CYP2A6 was the predominant drug-metabolizing enzyme involved in the metabolism of thymol and carvacrol. All these results remind the researchers that special attention should be paid on pharmacokinetic and clinical outcomes when thymol or carvacrol was co-administrated with other compounds mainly undergoing CYP2A6-mediated metabolism." @default.
- W67345071 created "2016-06-24" @default.
- W67345071 creator A5000316217 @default.
- W67345071 creator A5004775159 @default.
- W67345071 creator A5015282914 @default.
- W67345071 creator A5031928455 @default.
- W67345071 creator A5032155655 @default.
- W67345071 creator A5045679168 @default.
- W67345071 creator A5057110014 @default.
- W67345071 creator A5063542416 @default.
- W67345071 creator A5085353674 @default.
- W67345071 date "2012-12-01" @default.
- W67345071 modified "2023-10-11" @default.
- W67345071 title "Identification of CYP isoforms involved in the metabolism of thymol and carvacrol in human liver microsomes (HLMs)." @default.
- W67345071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23346763" @default.
- W67345071 hasPublicationYear "2012" @default.
- W67345071 type Work @default.
- W67345071 sameAs 67345071 @default.
- W67345071 citedByCount "3" @default.
- W67345071 countsByYear W673450712015 @default.
- W67345071 countsByYear W673450712017 @default.
- W67345071 countsByYear W673450712023 @default.
- W67345071 crossrefType "journal-article" @default.
- W67345071 hasAuthorship W67345071A5000316217 @default.
- W67345071 hasAuthorship W67345071A5004775159 @default.
- W67345071 hasAuthorship W67345071A5015282914 @default.
- W67345071 hasAuthorship W67345071A5031928455 @default.
- W67345071 hasAuthorship W67345071A5032155655 @default.
- W67345071 hasAuthorship W67345071A5045679168 @default.
- W67345071 hasAuthorship W67345071A5057110014 @default.
- W67345071 hasAuthorship W67345071A5063542416 @default.
- W67345071 hasAuthorship W67345071A5085353674 @default.
- W67345071 hasConcept C109650736 @default.
- W67345071 hasConcept C181199279 @default.
- W67345071 hasConcept C185592680 @default.
- W67345071 hasConcept C196013638 @default.
- W67345071 hasConcept C2777278459 @default.
- W67345071 hasConcept C2777477808 @default.
- W67345071 hasConcept C2777671706 @default.
- W67345071 hasConcept C2780642067 @default.
- W67345071 hasConcept C2780676017 @default.
- W67345071 hasConcept C2781109383 @default.
- W67345071 hasConcept C43617362 @default.
- W67345071 hasConcept C526171541 @default.
- W67345071 hasConcept C55493867 @default.
- W67345071 hasConcept C62231903 @default.
- W67345071 hasConcept C86803240 @default.
- W67345071 hasConcept C87644729 @default.
- W67345071 hasConcept C89311334 @default.
- W67345071 hasConcept C98274493 @default.
- W67345071 hasConceptScore W67345071C109650736 @default.
- W67345071 hasConceptScore W67345071C181199279 @default.
- W67345071 hasConceptScore W67345071C185592680 @default.
- W67345071 hasConceptScore W67345071C196013638 @default.
- W67345071 hasConceptScore W67345071C2777278459 @default.
- W67345071 hasConceptScore W67345071C2777477808 @default.
- W67345071 hasConceptScore W67345071C2777671706 @default.
- W67345071 hasConceptScore W67345071C2780642067 @default.
- W67345071 hasConceptScore W67345071C2780676017 @default.
- W67345071 hasConceptScore W67345071C2781109383 @default.
- W67345071 hasConceptScore W67345071C43617362 @default.
- W67345071 hasConceptScore W67345071C526171541 @default.
- W67345071 hasConceptScore W67345071C55493867 @default.
- W67345071 hasConceptScore W67345071C62231903 @default.
- W67345071 hasConceptScore W67345071C86803240 @default.
- W67345071 hasConceptScore W67345071C87644729 @default.
- W67345071 hasConceptScore W67345071C89311334 @default.
- W67345071 hasConceptScore W67345071C98274493 @default.
- W67345071 hasIssue "12" @default.
- W67345071 hasLocation W673450711 @default.
- W67345071 hasOpenAccess W67345071 @default.
- W67345071 hasPrimaryLocation W673450711 @default.
- W67345071 hasRelatedWork W1592027840 @default.
- W67345071 hasRelatedWork W2016088275 @default.
- W67345071 hasRelatedWork W2049186194 @default.
- W67345071 hasRelatedWork W2059347789 @default.
- W67345071 hasRelatedWork W2065670181 @default.
- W67345071 hasRelatedWork W2090709712 @default.
- W67345071 hasRelatedWork W2118533407 @default.
- W67345071 hasRelatedWork W2118545690 @default.
- W67345071 hasRelatedWork W2398565833 @default.
- W67345071 hasRelatedWork W67345071 @default.
- W67345071 hasVolume "67" @default.
- W67345071 isParatext "false" @default.
- W67345071 isRetracted "false" @default.
- W67345071 magId "67345071" @default.
- W67345071 workType "article" @default.