Matches in SemOpenAlex for { <https://semopenalex.org/work/W67375919> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W67375919 endingPage "8" @default.
- W67375919 startingPage "430" @default.
- W67375919 abstract "Effects of repeated oral administration of a commercial preparation of antitussive and expectorant, BRON-W Solution (SS Pharmaceut., BRON; 10ml/kg), and of single and combination of dihydrocodeine (2HCOD; 10mg/kg), methylephedrine (MEPH; 20mg/kg), caffeine (CAF; 20.6mg/kg) and chloropheniramine (CPA; 4mg/kg) were investigated by means of ambulatory activity in mice. The drug doses tested were identical with those in BRON 10ml/kg. The drug administration was conducted 5 times at intervals of 3-4 days. Furthermore, 4 days after the final treatments, all mice were given methamphetamine 2 mg/kg s.c. In the single administration regimen of individual drugs, only CAF significantly increased the ambulatory activity. However, there was no significant change in the ambulation-increasing effect of CAF after the repeated administration. The other 3 drugs failed to elicit any marked change in the activity throughout the 5 times administration. Such the repeated administration of the individual drugs induced no significant change in the sensitivity to the ambulation-increasing effect of methamphetamine. BRON and BRON-corresponding combination of 4 drugs increased the ambulatory activity in the 1st administration, and the ambulation-increasing effect was progressively enhanced by the repeated administration of these preparations. On the other hand, although CAF-containing solutions significantly increased the ambulatory activity in the 1st administration, the proportions of the changes in the ambulatory activity during the repeated administration regimen were different from that observed after BRON. The combined administration of 2HCOD + MEPH + CPA failed to increase the ambulatory activity in the 1st administration, but significantly increased it in the 2nd and 3rd administration, then elicited again no significant increase in the activity in the 4th and 5th administration.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W67375919 created "2016-06-24" @default.
- W67375919 creator A5085022072 @default.
- W67375919 creator A5087180865 @default.
- W67375919 date "1989-10-01" @default.
- W67375919 modified "2023-09-23" @default.
- W67375919 title "[Behavioral study on an antitussive and expectorant, and of its constituents. II. Effects on ambulatory activity after repeated administration, and a modification of the methamphetamine sensitivity in mice]." @default.
- W67375919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2624571" @default.
- W67375919 hasPublicationYear "1989" @default.
- W67375919 type Work @default.
- W67375919 sameAs 67375919 @default.
- W67375919 citedByCount "0" @default.
- W67375919 crossrefType "journal-article" @default.
- W67375919 hasAuthorship W67375919A5085022072 @default.
- W67375919 hasAuthorship W67375919A5087180865 @default.
- W67375919 hasConcept C126322002 @default.
- W67375919 hasConcept C2777056448 @default.
- W67375919 hasConcept C2778500429 @default.
- W67375919 hasConcept C2780376393 @default.
- W67375919 hasConcept C2909092086 @default.
- W67375919 hasConcept C2987276129 @default.
- W67375919 hasConcept C35785553 @default.
- W67375919 hasConcept C42219234 @default.
- W67375919 hasConcept C556039675 @default.
- W67375919 hasConcept C71924100 @default.
- W67375919 hasConcept C98274493 @default.
- W67375919 hasConceptScore W67375919C126322002 @default.
- W67375919 hasConceptScore W67375919C2777056448 @default.
- W67375919 hasConceptScore W67375919C2778500429 @default.
- W67375919 hasConceptScore W67375919C2780376393 @default.
- W67375919 hasConceptScore W67375919C2909092086 @default.
- W67375919 hasConceptScore W67375919C2987276129 @default.
- W67375919 hasConceptScore W67375919C35785553 @default.
- W67375919 hasConceptScore W67375919C42219234 @default.
- W67375919 hasConceptScore W67375919C556039675 @default.
- W67375919 hasConceptScore W67375919C71924100 @default.
- W67375919 hasConceptScore W67375919C98274493 @default.
- W67375919 hasIssue "5" @default.
- W67375919 hasLocation W673759191 @default.
- W67375919 hasOpenAccess W67375919 @default.
- W67375919 hasPrimaryLocation W673759191 @default.
- W67375919 hasRelatedWork W1751136425 @default.
- W67375919 hasRelatedWork W177866514 @default.
- W67375919 hasRelatedWork W2072779953 @default.
- W67375919 hasRelatedWork W2082745811 @default.
- W67375919 hasRelatedWork W2090356052 @default.
- W67375919 hasRelatedWork W2129224176 @default.
- W67375919 hasRelatedWork W2340207551 @default.
- W67375919 hasRelatedWork W2414970480 @default.
- W67375919 hasRelatedWork W3144175889 @default.
- W67375919 hasRelatedWork W67375919 @default.
- W67375919 hasVolume "24" @default.
- W67375919 isParatext "false" @default.
- W67375919 isRetracted "false" @default.
- W67375919 magId "67375919" @default.
- W67375919 workType "article" @default.