Matches in SemOpenAlex for { <https://semopenalex.org/work/W6739692> ?p ?o ?g. }
- W6739692 endingPage "29" @default.
- W6739692 startingPage "9" @default.
- W6739692 abstract "The nitrogen mustards are an important group of alkylating agents with activity against several human tumors (1–4). Many nitrogen mustard analogs are transported by carrier-mediated systems into cells and alkylate DNA, RNA, and proteins (5–7). Alkylation of DNA and, more specifically, the formation of DNA interstrand crosslinks have been considered to be responsible for their cytotoxicity (8–10). Resistance to the nitrogen mustards in murine and human tumor cells has been reported to be secondary to (1) alterations in the transport of these agents (11), (2) alterations in the kinetics of the DNA crosslinks formed by these agents (9,10,12), (3) cytoplasmic metabolism of the chloroethyl alkylating moiety to the inactive hydroxyethyl derivative (13) via glutathione (GSH)/ glutathione-S-transferase (GST) (14–16), (4) overexpression of metallothionein, which confers resistance to cis-platinum and cross-resistance to melphalan (17), (5) changes in resistance to apoptosis (18), and (6) altered DNA repair activity (se e Fig. 1) (19). There have been previous reports of alterations in the kinetics of DNA interstrand crosslink formation and removal associated with resistance to the nitrogen mustards (9,10,12), although others have found no differences in the ability of sensitive or resistant cells to remove nitrogen mustard-induced crosslinks (20, 21). This review will concentrate on the involvement of DNA repair in nitrogen mustard drug resistance and cross-resistance to cisplatin. We will discuss results obtained in clinical samples and human cancer cell lines." @default.
- W6739692 created "2016-06-24" @default.
- W6739692 creator A5005764534 @default.
- W6739692 creator A5017472427 @default.
- W6739692 creator A5047488202 @default.
- W6739692 date "2004-01-01" @default.
- W6739692 modified "2023-09-23" @default.
- W6739692 title "Role of Nonhomologous End-Joining and Recombinational DNA Repair in Resistance to Nitrogen Mustard and DNA Crosslinking Agents" @default.
- W6739692 cites W1480741751 @default.
- W6739692 cites W1483190045 @default.
- W6739692 cites W1499868220 @default.
- W6739692 cites W1509374324 @default.
- W6739692 cites W1513336448 @default.
- W6739692 cites W1518693320 @default.
- W6739692 cites W1541806623 @default.
- W6739692 cites W1563535689 @default.
- W6739692 cites W1652844913 @default.
- W6739692 cites W1806120780 @default.
- W6739692 cites W1832288685 @default.
- W6739692 cites W1850798365 @default.
- W6739692 cites W1887000748 @default.
- W6739692 cites W1887249279 @default.
- W6739692 cites W1910704132 @default.
- W6739692 cites W1947282333 @default.
- W6739692 cites W1959049775 @default.
- W6739692 cites W1966092175 @default.
- W6739692 cites W1970577073 @default.
- W6739692 cites W1971730609 @default.
- W6739692 cites W1972562299 @default.
- W6739692 cites W1974375149 @default.
- W6739692 cites W1980075357 @default.
- W6739692 cites W1981485296 @default.
- W6739692 cites W1983491625 @default.
- W6739692 cites W1985504590 @default.
- W6739692 cites W1987003289 @default.
- W6739692 cites W1987446818 @default.
- W6739692 cites W1987579714 @default.
- W6739692 cites W1989339075 @default.
- W6739692 cites W1994745029 @default.
- W6739692 cites W1997759534 @default.
- W6739692 cites W2005312277 @default.
- W6739692 cites W2006342215 @default.
- W6739692 cites W2007222488 @default.
- W6739692 cites W2012090280 @default.
- W6739692 cites W2012845469 @default.
- W6739692 cites W2014886324 @default.
- W6739692 cites W2015130934 @default.
- W6739692 cites W2018295619 @default.
- W6739692 cites W2024954071 @default.
- W6739692 cites W2029526485 @default.
- W6739692 cites W2029881378 @default.
- W6739692 cites W2040323503 @default.
- W6739692 cites W2043527294 @default.
- W6739692 cites W2043593588 @default.
- W6739692 cites W2043877228 @default.
- W6739692 cites W2049208988 @default.
- W6739692 cites W2061078249 @default.
- W6739692 cites W2065136741 @default.
- W6739692 cites W2082249342 @default.
- W6739692 cites W2086389702 @default.
- W6739692 cites W2088801588 @default.
- W6739692 cites W2090263062 @default.
- W6739692 cites W2101302116 @default.
- W6739692 cites W2102450463 @default.
- W6739692 cites W2102455302 @default.
- W6739692 cites W2104445464 @default.
- W6739692 cites W2104788350 @default.
- W6739692 cites W2106773063 @default.
- W6739692 cites W2108036654 @default.
- W6739692 cites W2108041634 @default.
- W6739692 cites W2113796216 @default.
- W6739692 cites W2124604393 @default.
- W6739692 cites W2124739180 @default.
- W6739692 cites W2128252882 @default.
- W6739692 cites W2130730147 @default.
- W6739692 cites W2133318290 @default.
- W6739692 cites W2137211272 @default.
- W6739692 cites W2137347518 @default.
- W6739692 cites W2140924252 @default.
- W6739692 cites W2148361462 @default.
- W6739692 cites W2156758009 @default.
- W6739692 cites W2165848530 @default.
- W6739692 cites W2167120728 @default.
- W6739692 cites W2168604096 @default.
- W6739692 cites W2168823709 @default.
- W6739692 cites W2172247857 @default.
- W6739692 cites W2297284353 @default.
- W6739692 cites W2305848735 @default.
- W6739692 cites W2321405682 @default.
- W6739692 cites W2327174419 @default.
- W6739692 cites W2332359486 @default.
- W6739692 cites W2332499236 @default.
- W6739692 cites W2333408219 @default.
- W6739692 cites W2339705539 @default.
- W6739692 cites W2398240122 @default.
- W6739692 cites W2417418092 @default.
- W6739692 cites W2424847782 @default.
- W6739692 cites W2425956429 @default.