Matches in SemOpenAlex for { <https://semopenalex.org/work/W67407384> ?p ?o ?g. }
- W67407384 abstract "It is now well established that Na+-K+ ATPase is primarily localized in the sarcolemmal membrane in the myocardium (1,2). This enzyme is intimately involved in the transport of Na+ and K+ and is thus considered to maintain the electrochemical gradient across the cell membrane which allows depolarization to occur. An inhibition of Na+-K+ ATPase activity has been shown to increase the intracellular concentration of Na+, which then increases the cytoplasmic level of Ca 2+ through Na +-Ca 2+ exchange system in the plasma membrane and thus has been proposed to serve as a mechanism of the positive inotropic action of cardiac glycosides (digitalis). Although Na+-K+ ATPase is known to possess high and low affinity sites for cardiac glycosides, the exact significance of these sites is not clear at present (3). Since the intracellular concentration of Na + has been shown to regulate myocardial contractility (4), any change in the operation of sarcolemmal Na+-K+ ATPase activity can be seen to alter Ca2+ ion movements in the cell and thus modify the heart function. Accordingly, a great deal of attention has been focussed on elucidation of the function of this enzyme in both health and disease." @default.
- W67407384 created "2016-06-24" @default.
- W67407384 creator A5037459846 @default.
- W67407384 creator A5043395523 @default.
- W67407384 creator A5068857226 @default.
- W67407384 date "1993-01-01" @default.
- W67407384 modified "2023-09-27" @default.
- W67407384 title "Involvement of Sarcolemmal Na+-K+ ATPase in the Pathogenesis of Heart Disease" @default.
- W67407384 cites W1529141639 @default.
- W67407384 cites W1972538652 @default.
- W67407384 cites W1984444508 @default.
- W67407384 cites W1989109033 @default.
- W67407384 cites W1994594631 @default.
- W67407384 cites W2008349061 @default.
- W67407384 cites W2016607535 @default.
- W67407384 cites W2018285489 @default.
- W67407384 cites W2018657992 @default.
- W67407384 cites W2021583097 @default.
- W67407384 cites W2021727842 @default.
- W67407384 cites W2024105264 @default.
- W67407384 cites W2030372328 @default.
- W67407384 cites W2053322929 @default.
- W67407384 cites W2058824097 @default.
- W67407384 cites W2063051706 @default.
- W67407384 cites W2063149789 @default.
- W67407384 cites W2066936996 @default.
- W67407384 cites W2067204054 @default.
- W67407384 cites W2068955622 @default.
- W67407384 cites W2078597495 @default.
- W67407384 cites W2083136009 @default.
- W67407384 cites W2084421019 @default.
- W67407384 cites W2088832738 @default.
- W67407384 cites W2096136250 @default.
- W67407384 cites W2099130096 @default.
- W67407384 cites W2112055017 @default.
- W67407384 cites W2114711724 @default.
- W67407384 cites W2126003009 @default.
- W67407384 cites W2127968679 @default.
- W67407384 cites W2130935973 @default.
- W67407384 cites W2160261406 @default.
- W67407384 cites W2190422810 @default.
- W67407384 cites W2205813557 @default.
- W67407384 cites W2264309193 @default.
- W67407384 cites W2267699182 @default.
- W67407384 cites W2317790469 @default.
- W67407384 cites W2413368033 @default.
- W67407384 cites W2416196817 @default.
- W67407384 cites W4243861659 @default.
- W67407384 doi "https://doi.org/10.1007/978-1-4615-3090-9_22" @default.
- W67407384 hasPublicationYear "1993" @default.
- W67407384 type Work @default.
- W67407384 sameAs 67407384 @default.
- W67407384 citedByCount "1" @default.
- W67407384 countsByYear W674073842015 @default.
- W67407384 crossrefType "book-chapter" @default.
- W67407384 hasAuthorship W67407384A5037459846 @default.
- W67407384 hasAuthorship W67407384A5043395523 @default.
- W67407384 hasAuthorship W67407384A5068857226 @default.
- W67407384 hasConcept C12554922 @default.
- W67407384 hasConcept C126322002 @default.
- W67407384 hasConcept C155710745 @default.
- W67407384 hasConcept C178790620 @default.
- W67407384 hasConcept C181199279 @default.
- W67407384 hasConcept C185592680 @default.
- W67407384 hasConcept C190062978 @default.
- W67407384 hasConcept C199096232 @default.
- W67407384 hasConcept C23265538 @default.
- W67407384 hasConcept C2776445394 @default.
- W67407384 hasConcept C2778198053 @default.
- W67407384 hasConcept C2779133857 @default.
- W67407384 hasConcept C39133596 @default.
- W67407384 hasConcept C41625074 @default.
- W67407384 hasConcept C537181965 @default.
- W67407384 hasConcept C55493867 @default.
- W67407384 hasConcept C71924100 @default.
- W67407384 hasConcept C79879829 @default.
- W67407384 hasConcept C86803240 @default.
- W67407384 hasConcept C99975950 @default.
- W67407384 hasConceptScore W67407384C12554922 @default.
- W67407384 hasConceptScore W67407384C126322002 @default.
- W67407384 hasConceptScore W67407384C155710745 @default.
- W67407384 hasConceptScore W67407384C178790620 @default.
- W67407384 hasConceptScore W67407384C181199279 @default.
- W67407384 hasConceptScore W67407384C185592680 @default.
- W67407384 hasConceptScore W67407384C190062978 @default.
- W67407384 hasConceptScore W67407384C199096232 @default.
- W67407384 hasConceptScore W67407384C23265538 @default.
- W67407384 hasConceptScore W67407384C2776445394 @default.
- W67407384 hasConceptScore W67407384C2778198053 @default.
- W67407384 hasConceptScore W67407384C2779133857 @default.
- W67407384 hasConceptScore W67407384C39133596 @default.
- W67407384 hasConceptScore W67407384C41625074 @default.
- W67407384 hasConceptScore W67407384C537181965 @default.
- W67407384 hasConceptScore W67407384C55493867 @default.
- W67407384 hasConceptScore W67407384C71924100 @default.
- W67407384 hasConceptScore W67407384C79879829 @default.
- W67407384 hasConceptScore W67407384C86803240 @default.
- W67407384 hasConceptScore W67407384C99975950 @default.
- W67407384 hasLocation W674073841 @default.
- W67407384 hasOpenAccess W67407384 @default.