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- W67539249 abstract "Abstract Regulatory T cells (Tregs) play a pivotal role in the suppression of tumour antigen responses. It is well established that balb/c mice depleted of Tregs, using the anti-CD25 antibody pc61, are capable of rejecting the colon carcinoma line CT26. Mice challenged with CT26 in these circumstances have also been shown to reject a further challenge with CT26 or a second tumour line. The antigens responsible for this rejection are only partially characterised, with MHC class 1 antigens known to be restricted to all three H2-D molecules. Our laboratory has identified a Dd restricted antigen, GSW11, which is largely responsible for the cross protective response. Investigation into the processing of GSW11 revealed a sensitivity to over-processing by Eraap. In an attempt to increase the immunogenicity we generated Eraap knockdown CT26 using a plasmid knockdown system. These CT26 derivatives with reduced Eraap mRNA and protein levels were found to stimulate a peptide specific hybridoma more than wild type CT26. In addition, balb/c mice challenged with Eraap knockdown CT26 gained an 80% protection verses 0% mice injected with wild type CT26. Further experimentation is being undertaken to elucidate the exact mechanisms behind this protection." @default.
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- W67539249 date "2009-04-01" @default.
- W67539249 modified "2023-10-18" @default.
- W67539249 title "Eraap knockdown in CT26 alters antigenic response to the tumour invivo (78.39)" @default.
- W67539249 doi "https://doi.org/10.4049/jimmunol.182.supp.78.39" @default.
- W67539249 hasPublicationYear "2009" @default.
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