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- W67546472 abstract "This chapter describes the antibody-mediated immunosuppression as a model for antibody feedback dealing especially with the role that the Fc portion of antibody has in this form of control. The suppression of immune responses by antibody or antigen–antibody complexes through an Fc-dependent mechanism can be amplified by the radiosensitive production of suppressor cells. The proximal stimulator of suppressor cell activity may be exposure to an Fc signal in antigen–antibody complexes. A portion of human suppressor T cells display Fc receptors for IgG and murine T cells elaborate an Fc-binding protein containing H-2I antigens, which has suppressive properties. In general, there are two ways to view the induction of immune responses. In both cases, one can begin with the concept that antigen receptors and various types of cells are produced by a genetic mechanism in concert with influences emanating from the internal and external environment. The system may be controlled in one of two ways. First, the immune system may require a series of positive, inducing signals other than antigen binding in order to become activated. Most concepts of immune response activation begin with this assumption and need not be elaborated on further. A second approach is to consider that effector cell precursors have, as a basic characteristic, the ability to respond without help but are prevented from completing the process because of powerful end-product feedback." @default.
- W67546472 created "2016-06-24" @default.
- W67546472 creator A5059068559 @default.
- W67546472 date "1980-01-01" @default.
- W67546472 modified "2023-09-29" @default.
- W67546472 title "REGULATION BY ANTIBODY FEEDBACK AND OTHER NONACTIVE SITE CONTROL" @default.
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- W67546472 doi "https://doi.org/10.1016/b978-0-12-637140-6.50020-6" @default.
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