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- W6755782 abstract "Age-related mitochondrial dysfunction is paralleled by reductions in gene transcripts and expression of proteins involved in cellular ATP production. Short-term endurance exercise has been shown to enhance muscle protein synthesis in the elderly. We determined the impact of long-term endurance exercise on gene expression and protein abundance of numerous proteins involved in cellular energetics. Vastus lateralis tissue was biopsied from 11 young sedentary (YS), 10 old sedentary (OS), 11 young trained (YT), and 11 old trained (OT) subjects. Trained subjects vigorously exercised ¡Ý 1 hr/d, ¡Ý five d/wk for ¡Ý 4 years. Large-scale measurement of relative protein abundance was performed using isobaric tags for relative and absolute quantitation (iTRAQ) reagents and tandem mass spectrometry. Gene transcript levels were measured by high-density oligonucleotide microarrays. Ingenuity Pathway Analysis was used to determine canonical pathways that were altered by age. Of the 33 proteins involved in cellular ATP production 27 were less abundant in OS vs. YS, while only 4 of these proteins were less abundant in OT vs. YT. Genes involved in glycolysis and oxidative phosphorylation were underexpressed in OS vs. YS, with no effects of age in OT vs. YT. CONCLUSIONS: Long-term vigorous endurance exercise ameliorates the detrimental effects of old age on muscle gene and protein expression in humans." @default.
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- W6755782 date "2008-03-01" @default.
- W6755782 modified "2023-09-25" @default.
- W6755782 title "The Impact of Long‐Term Physical Activity on Age‐Related Changes in Protein and Gene Expression" @default.
- W6755782 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1163.21" @default.
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