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• W67567034 abstract "Brain slices are an in vitro preparation used to simplify the complexity of the brain by isolating particular regions of interest. Dopamine neurons have been found to function differently under current brain slice protocols than in vivo. To improve the worth of the information gained from brain slice experiments, it must be determined which elements of the in vivo environment are important to normal function. Making these determinations is central to this dissertation. Carbon-fiber microelectrodes were used to monitor electrically stimulated dopamine release in brain slices with fast-scan cyclic voltammetry (FSCV). The first question asked is what role extracellular dopamine tone plays in controlling dopamine release. Basal dopamine tone in vivo stimulates D2 autoreceptors, which regulate dopamine release; however, in brain slices, there is no dopamine tone. Therefore, determining proper autoreceptor activation is important to making release biologically relevant. Second, neurons fire action potentials along their axons to cause release at their terminals. In brain slice experiments stimulation occurs at the nerve terminals. To stimulate at the axons requires visualization of the dopamine neurons. Two transgenic mouse models that make dopaminergic cells visible due to their fluorescence are evaluated. Lastly, electrochemical and immunohistochemical methods are used to account for norepinephrine and serotonin in these brain slices. D2 autoreceptor stimulation, proper electrode placement, and the appropriate electrochemical approach are found to be important for improving current brain slice methodology." @default.
• W67567034 created "2016-06-24" @default.
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• W67567034 date "2008-08-01" @default.
• W67567034 modified "2023-09-24" @default.
• W67567034 title "Improving Brain Slice Methodology" @default.
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• W67567034 hasPublicationYear "2008" @default.
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