Matches in SemOpenAlex for { <https://semopenalex.org/work/W6760901> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W6760901 endingPage "L966" @default.
- W6760901 startingPage "L958" @default.
- W6760901 abstract "Triptolide (PG490, 97% pure) is a diterpenoid triepoxide with potent anti-inflammatory and immunosuppressive effects in transformed human bronchial epithelial cells and T cells (Qiu D, Zhao G, Aoki Y, Shi L, Uyei A, Nazarian S, Ng JC-H, and Kao PN. J Biol Chem 274: 13443-13450, 1999). Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta. Nuclear runoff and luciferase reporter gene assays demonstrate that triptolide inhibits IL-8 transcription. Triptolide also inhibits the transcriptional activation, but not the DNA binding, of nuclear factor-kappa B. A cDNA array and clustering algorithm analysis reveals that triptolide inhibits expression of the PMA-induced genes tumor necrosis factor-alpha, IL-8, macrophage inflammatory protein-2 alpha, intercellular adhesion molecule-1, integrin beta(6), vascular endothelial growth factor, granulocyte-macrophage colony-stimulating factor, GATA-3, fra-1, and NF45. Triptolide also inhibits constitutively expressed cell cycle regulators and survival genes cyclins D1, B1, and A1, cdc-25, bcl-x, and c-jun. Thus anti-inflammatory, antiproliferative, and proapoptotic properties of triptolide are associated with inhibition of nuclear factor-kappa B signaling and inhibition of genes known to regulate cell cycle progression and survival." @default.
- W6760901 created "2016-06-24" @default.
- W6760901 creator A5015894942 @default.
- W6760901 creator A5064029106 @default.
- W6760901 creator A5074669378 @default.
- W6760901 creator A5082187566 @default.
- W6760901 creator A5083109517 @default.
- W6760901 date "2000-11-01" @default.
- W6760901 modified "2023-10-08" @default.
- W6760901 title "Anti-inflammatory effects of triptolide in human bronchial epithelial cells" @default.
- W6760901 cites W1573683888 @default.
- W6760901 cites W1592606160 @default.
- W6760901 cites W1601862559 @default.
- W6760901 cites W1636221253 @default.
- W6760901 cites W169134854 @default.
- W6760901 cites W1888783223 @default.
- W6760901 cites W1969791237 @default.
- W6760901 cites W1978239407 @default.
- W6760901 cites W1986643690 @default.
- W6760901 cites W2036904310 @default.
- W6760901 cites W2082575834 @default.
- W6760901 cites W2106849532 @default.
- W6760901 cites W2150926065 @default.
- W6760901 cites W2151892297 @default.
- W6760901 cites W2163166029 @default.
- W6760901 cites W2164925666 @default.
- W6760901 cites W2166781237 @default.
- W6760901 cites W2181411157 @default.
- W6760901 cites W2188589597 @default.
- W6760901 cites W2337296963 @default.
- W6760901 cites W56747938 @default.
- W6760901 doi "https://doi.org/10.1152/ajplung.2000.279.5.l958" @default.
- W6760901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11053033" @default.
- W6760901 hasPublicationYear "2000" @default.
- W6760901 type Work @default.
- W6760901 sameAs 6760901 @default.
- W6760901 citedByCount "79" @default.
- W6760901 countsByYear W67609012012 @default.
- W6760901 countsByYear W67609012013 @default.
- W6760901 countsByYear W67609012014 @default.
- W6760901 countsByYear W67609012015 @default.
- W6760901 countsByYear W67609012016 @default.
- W6760901 countsByYear W67609012017 @default.
- W6760901 countsByYear W67609012018 @default.
- W6760901 countsByYear W67609012019 @default.
- W6760901 countsByYear W67609012020 @default.
- W6760901 countsByYear W67609012021 @default.
- W6760901 countsByYear W67609012023 @default.
- W6760901 crossrefType "journal-article" @default.
- W6760901 hasAuthorship W6760901A5015894942 @default.
- W6760901 hasAuthorship W6760901A5064029106 @default.
- W6760901 hasAuthorship W6760901A5074669378 @default.
- W6760901 hasAuthorship W6760901A5082187566 @default.
- W6760901 hasAuthorship W6760901A5083109517 @default.
- W6760901 hasConcept C153911025 @default.
- W6760901 hasConcept C17991360 @default.
- W6760901 hasConcept C185592680 @default.
- W6760901 hasConcept C190283241 @default.
- W6760901 hasConcept C203014093 @default.
- W6760901 hasConcept C2781164371 @default.
- W6760901 hasConcept C29537977 @default.
- W6760901 hasConcept C502942594 @default.
- W6760901 hasConcept C55493867 @default.
- W6760901 hasConcept C86803240 @default.
- W6760901 hasConcept C95444343 @default.
- W6760901 hasConceptScore W6760901C153911025 @default.
- W6760901 hasConceptScore W6760901C17991360 @default.
- W6760901 hasConceptScore W6760901C185592680 @default.
- W6760901 hasConceptScore W6760901C190283241 @default.
- W6760901 hasConceptScore W6760901C203014093 @default.
- W6760901 hasConceptScore W6760901C2781164371 @default.
- W6760901 hasConceptScore W6760901C29537977 @default.
- W6760901 hasConceptScore W6760901C502942594 @default.
- W6760901 hasConceptScore W6760901C55493867 @default.
- W6760901 hasConceptScore W6760901C86803240 @default.
- W6760901 hasConceptScore W6760901C95444343 @default.
- W6760901 hasIssue "5" @default.
- W6760901 hasLocation W67609011 @default.
- W6760901 hasLocation W67609012 @default.
- W6760901 hasOpenAccess W6760901 @default.
- W6760901 hasPrimaryLocation W67609011 @default.
- W6760901 hasRelatedWork W2000073552 @default.
- W6760901 hasRelatedWork W2034366718 @default.
- W6760901 hasRelatedWork W2094781908 @default.
- W6760901 hasRelatedWork W2301156966 @default.
- W6760901 hasRelatedWork W2348642629 @default.
- W6760901 hasRelatedWork W2353118491 @default.
- W6760901 hasRelatedWork W2355829838 @default.
- W6760901 hasRelatedWork W2360393974 @default.
- W6760901 hasRelatedWork W2368630945 @default.
- W6760901 hasRelatedWork W2385319251 @default.
- W6760901 hasVolume "279" @default.
- W6760901 isParatext "false" @default.
- W6760901 isRetracted "false" @default.
- W6760901 magId "6760901" @default.
- W6760901 workType "article" @default.