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- W67646724 abstract "Publisher Summary This chapter discusses the cloned lines of mouse natural killer (NK) cells. Recently, cultured lines and clones of NK cells have been established with IL-2 from the spleen of nonimmunized mice. Their cytotoxic activity had similar patterns of reactivity as fresh spleen cells against a panel of NK-sensitive and NK-resistant tumor lines. The detailed studies of such NK clones are useful to understand the specificity of NK reactivity and particularly to determine whether NK clones demonstrate heterogeneous patterns of reactivity. The initial frequencies of proliferating cytotoxic cells from the spleens of SJL mice were quite low, as might be expected for a strain with low NK activity. The levels of cytotoxic activity by some of the clones were quite high, comparable to those seen with cultures from some high or intermediate NK strains. The results indicate that a low NK strain like SJL has some cells with the inherent ability to be highly cytotoxic, and the initially low reactivity may be caused by either a low frequency of cytotoxic cells and their progenitors or to the presence of suppressor cells that may interfere with the proliferation of cytotoxic cells and with the effector phase." @default.
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- W67646724 date "1982-01-01" @default.
- W67646724 modified "2023-09-27" @default.
- W67646724 title "CLONED LINES OF MOUSE NATURAL KILLER CELLS" @default.
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- W67646724 doi "https://doi.org/10.1016/b978-0-12-341360-4.50131-1" @default.
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