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- W67650390 abstract "Publisher Summary This chapter discusses cytostatic factor and chromosome behavior in early development. The cytostatic factor (CSF) appears to be responsible for the meiotic arrest of the oocyte prior to fertilization. Therefore, its inactivation by insemination or by parthenogenetic activation may be considered to be a cause of the resumption of meiosis as well as of the initiation of mitosis. Any substance that meets the criteria for CSF must be unstable in character. In the experiments discusses in the chapter, the cleavage-arresting effect of CSF on blastomeres can usually be observed in Rana when a blastomere of 2-cell embryos was injected with 60nl of egg cytoplasm or cytoplasmic extract from unfertilized eggs. Furthermore, as the bulk of cytoplasm in CSF-arrested blastomeres is able to induce metaphase chromosome condensation in nuclei exposed to it, the action of CSF was not localized, but appears to spread throughout the cytoplasm of the recipient cell." @default.
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- W67650390 date "1980-01-01" @default.
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- W67650390 title "Cytostatic Factor and Chromosome Behavior in Early Development" @default.
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- W67650390 doi "https://doi.org/10.1016/b978-0-12-612984-7.50021-9" @default.
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