Matches in SemOpenAlex for { <https://semopenalex.org/work/W67756551> ?p ?o ?g. }
- W67756551 endingPage "279" @default.
- W67756551 startingPage "255" @default.
- W67756551 abstract "Activation of cells by many extracellular agonists leads to the production of inositol 1,4,5-trisphosphate (IP₃). IP₃ is a global messenger that easily diffuses in the cytosol. Its receptor (IP₃R) is a Ca(2+)-release channel located on intracellular membranes, especially the endoplasmic reticulum (ER). The IP₃R has an affinity for IP(3) in the low nanomolar range. A prime regulator of the IP₃R is the Ca(2+) ion itself. Cytosolic Ca(2+) is considered as a co-agonist of the IP₃R, as it strongly increases IP(3)R activity at concentrations up to about 300 nM. In contrast, at higher concentrations, cytosolic Ca(2+) inhibits the IP₃R. Also the luminal Ca(2+) sensitizes the IP₃R. In higher organisms three genes encode for an IP₃R and additional diversity exists as a result of alternative splicing mechanisms and the formation of homo- and heterotetramers. The various IP₃R isoforms have a similar structure and a similar function, but due to differences in their affinity for IP₃, their variable sensitivity to regulatory parameters, their differential interaction with associated proteins, and the variation in their subcellular localization, they participate differently in the formation of intracellular Ca(2+) signals and this affects therefore the physiological consequences of these signals." @default.
- W67756551 created "2016-06-24" @default.
- W67756551 creator A5035800550 @default.
- W67756551 creator A5082879421 @default.
- W67756551 date "2012-01-01" @default.
- W67756551 modified "2023-10-12" @default.
- W67756551 title "Inositol 1,4,5-Trisphosphate and Its Receptors" @default.
- W67756551 cites W1491475975 @default.
- W67756551 cites W1496221368 @default.
- W67756551 cites W1518265004 @default.
- W67756551 cites W1519110908 @default.
- W67756551 cites W1523078822 @default.
- W67756551 cites W1526274619 @default.
- W67756551 cites W1533480923 @default.
- W67756551 cites W1538989554 @default.
- W67756551 cites W1545526300 @default.
- W67756551 cites W1551195741 @default.
- W67756551 cites W1551497686 @default.
- W67756551 cites W1555351713 @default.
- W67756551 cites W1556752542 @default.
- W67756551 cites W1564090547 @default.
- W67756551 cites W1569542125 @default.
- W67756551 cites W1583023128 @default.
- W67756551 cites W1586746737 @default.
- W67756551 cites W1597778600 @default.
- W67756551 cites W1598081743 @default.
- W67756551 cites W1599277155 @default.
- W67756551 cites W1603199903 @default.
- W67756551 cites W1729732610 @default.
- W67756551 cites W1754966016 @default.
- W67756551 cites W1788868849 @default.
- W67756551 cites W1802980406 @default.
- W67756551 cites W1926746605 @default.
- W67756551 cites W1964017923 @default.
- W67756551 cites W1966330107 @default.
- W67756551 cites W1971104049 @default.
- W67756551 cites W1971119290 @default.
- W67756551 cites W1972545408 @default.
- W67756551 cites W1975489718 @default.
- W67756551 cites W1976134600 @default.
- W67756551 cites W1976692819 @default.
- W67756551 cites W1976746355 @default.
- W67756551 cites W1979379468 @default.
- W67756551 cites W1980604810 @default.
- W67756551 cites W1981491992 @default.
- W67756551 cites W1981645566 @default.
- W67756551 cites W1982289450 @default.
- W67756551 cites W1983818019 @default.
- W67756551 cites W1984843607 @default.
- W67756551 cites W1988424651 @default.
- W67756551 cites W1989105619 @default.
- W67756551 cites W1990441076 @default.
- W67756551 cites W1994231550 @default.
- W67756551 cites W1994447752 @default.
- W67756551 cites W1994580024 @default.
- W67756551 cites W1994924034 @default.
- W67756551 cites W1997778815 @default.
- W67756551 cites W1997816574 @default.
- W67756551 cites W1998143771 @default.
- W67756551 cites W2000451431 @default.
- W67756551 cites W2001907971 @default.
- W67756551 cites W2002776551 @default.
- W67756551 cites W2003197964 @default.
- W67756551 cites W2003782545 @default.
- W67756551 cites W2007263885 @default.
- W67756551 cites W2008245136 @default.
- W67756551 cites W2008906006 @default.
- W67756551 cites W2009997286 @default.
- W67756551 cites W2010083809 @default.
- W67756551 cites W2012109738 @default.
- W67756551 cites W2013237838 @default.
- W67756551 cites W2013341079 @default.
- W67756551 cites W2013420237 @default.
- W67756551 cites W2013802663 @default.
- W67756551 cites W2014172541 @default.
- W67756551 cites W2015145843 @default.
- W67756551 cites W2015174816 @default.
- W67756551 cites W2015470840 @default.
- W67756551 cites W2015536770 @default.
- W67756551 cites W2018200055 @default.
- W67756551 cites W2018696172 @default.
- W67756551 cites W2021695126 @default.
- W67756551 cites W2021847777 @default.
- W67756551 cites W2022918606 @default.
- W67756551 cites W2025074530 @default.
- W67756551 cites W2027630654 @default.
- W67756551 cites W2029531386 @default.
- W67756551 cites W2031304662 @default.
- W67756551 cites W2032737049 @default.
- W67756551 cites W2032770343 @default.
- W67756551 cites W2034021984 @default.
- W67756551 cites W2035967549 @default.
- W67756551 cites W2038160847 @default.
- W67756551 cites W2039511414 @default.
- W67756551 cites W2039599376 @default.
- W67756551 cites W2039600625 @default.
- W67756551 cites W2045399399 @default.
- W67756551 cites W2045692472 @default.