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- W67964128 abstract "Findings are presented from matched case-control studies of risk factors for diabetes, cryptorchidismand inguinal hernia in children using routine data collected by the Oxford RecordLinkage Study since 1965.There were 315 cases born 1965-85 in the diabetes study, 947 and 1449 cases in studiesof cryptorchidism diagnosed at birth and at orchidopexy respectively, and 1701 male and347 female cases in the study of inguinal hernia. Each case was individually matched withup to eight controls on sex, year, and hospital or place of birth.A potential bias caused by differential migration of cases and controls was identified.A sample of 753 controls born in Oxfordshire was checked against the Oxfordshire FamilyHealth Services Authority register to determine migration out of the study area in relationto perinatal risk factors. A general procedure was developed to estimate the strength of themigration bias.Pre-eclampsia was identified as a significant pre-natal risk factor for diabetes. Thestudies of cryptorchidism identified significantly raised risks with low birth weight, low socialclass and breech presentation. The results suggested that asymmetric growth retardationin the third trimester may be involved in the aetiology of undescended testes that do notspontaneously descend in later life. Analysis of risk factors among siblings of cases andcontrols suggested that permanent changes to the mother may occur around the time of thepregnancy involving the affected child.Low birth weight, short gestation and smoking during pregnancy were associated withsignificantly raised risks of inguinal hernia among boys. Among girls the results were similar,suggesting that mechanisms independent of the sex of the child may be important in theaetiology of this condition. Estimates of disease risk in siblings showed a strong familialaggregation, especially among girls." @default.
- W67964128 created "2016-06-24" @default.
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- W67964128 date "1996-01-01" @default.
- W67964128 modified "2023-09-24" @default.
- W67964128 title "Pre-natal and early life risk factors for diabetes, cryptorchism and inguinal hernia in children." @default.
- W67964128 doi "https://doi.org/10.17037/pubs.00682237" @default.
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