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- W68000657 abstract "The first of the antiinfective agents belonging to the quinolone class was discovered 50 years ago. Since that time many thousands of analogs have been prepared and nearly two dozen examples have found clinical use. New agents are still being introduced at a significant pace and research continues to be intensive in this area. With the passage of time and the accretion of more and more evidence, a deeper understanding of how these agents work and the structural characteristics required for significant activity and freedom from toxicity has been achieved. The purpose of this chapter is to provide a summary view of the present state of the art. It is important, however, to bear in mind that several surprises have upset our confidence in the generality of conventional wisdom. This has occurred already several times in this therapeutic area and constitutes a warning against uncritical reliance on overinterpreted or generalized beliefs." @default.
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- W68000657 date "2003-01-01" @default.
- W68000657 modified "2023-09-25" @default.
- W68000657 title "Structure-activity relationships of quinolones" @default.
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- W68000657 doi "https://doi.org/10.1007/978-3-0348-8103-6_2" @default.
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