Matches in SemOpenAlex for { <https://semopenalex.org/work/W68074898> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W68074898 endingPage "3" @default.
- W68074898 startingPage "850" @default.
- W68074898 abstract "To investigate the cellular origin of nitric oxide released from the rabbit retina in response to physiological stimulation with light.The release of nitric oxide from the retina was measured in rabbits anesthetized with urethane. An eye-cup was prepared and was filled with Krebs-Ringer bicarbonate. After washing for 45 minutes, 0.5 ml medium was placed in the eyecup. The medium was replaced every 10 minutes, and nitric oxide in the resultant samples was measured using nitrate reductase and a nitric oxide meter.In the unstimulated dark-adapted retina there was a spontaneous resting release of nitric oxide (1.20 nmol/min). When the retina was stimulated for 10 minutes with flickering light there was an increase in nitric oxide release to almost double the resting release. Stimulation of the retina for 10 minutes with continuous light produced a similar increase in nitric oxide release. The exposure of the retina to L-amino-4-phosphonobutyrate (APB), which specifically blocks transmission between the photoreceptors and the depolarizing bipolar cells, abolished the evoked release of nitric oxide caused by flickering light and continuous light. In contrast, the nonselective excitatory amino acid antagonist cis-2,3-piperidinedicarboxylic acid (PDA) had no effect on the flicker-evoked release of nitric oxide, but it more than halved the release caused by continuous light. A similar differential effect on release was found with glycine, which abolished the nitric oxide release evoked with continuous light but did not affect the flicker-evoked release. The inhibitory effect of glycine was blocked by strychnine.Nitric oxide was released in the retina by flickering light and by continuous light, but the two types of stimulation cause nitric oxide release from different cells. Because in the rabbit retina nitric oxide synthase occurs mainly in a subpopulation of amacrine cells and a few bipolar cells, our pharmacologic results suggest that continuous light causes nitric oxide release from amacrine cells, whereas flickering light evokes nitric oxide release from bipolar cells." @default.
- W68074898 created "2016-06-24" @default.
- W68074898 creator A5019869735 @default.
- W68074898 creator A5049523338 @default.
- W68074898 creator A5061764940 @default.
- W68074898 date "1998-04-01" @default.
- W68074898 modified "2023-10-16" @default.
- W68074898 title "Selective release of nitric oxide from retinal amacrine and bipolar cells." @default.
- W68074898 cites W1740455381 @default.
- W68074898 cites W1964447771 @default.
- W68074898 cites W1968740148 @default.
- W68074898 cites W1969684757 @default.
- W68074898 cites W1980535963 @default.
- W68074898 cites W1997032540 @default.
- W68074898 cites W207162008 @default.
- W68074898 cites W2072060769 @default.
- W68074898 cites W2072759014 @default.
- W68074898 cites W2095018051 @default.
- W68074898 cites W2120339303 @default.
- W68074898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9538896" @default.
- W68074898 hasPublicationYear "1998" @default.
- W68074898 type Work @default.
- W68074898 sameAs 68074898 @default.
- W68074898 citedByCount "17" @default.
- W68074898 countsByYear W680748982014 @default.
- W68074898 countsByYear W680748982015 @default.
- W68074898 countsByYear W680748982016 @default.
- W68074898 countsByYear W680748982018 @default.
- W68074898 countsByYear W680748982019 @default.
- W68074898 countsByYear W680748982021 @default.
- W68074898 crossrefType "journal-article" @default.
- W68074898 hasAuthorship W68074898A5019869735 @default.
- W68074898 hasAuthorship W68074898A5049523338 @default.
- W68074898 hasAuthorship W68074898A5061764940 @default.
- W68074898 hasConcept C12554922 @default.
- W68074898 hasConcept C134018914 @default.
- W68074898 hasConcept C169760540 @default.
- W68074898 hasConcept C178790620 @default.
- W68074898 hasConcept C185592680 @default.
- W68074898 hasConcept C24998067 @default.
- W68074898 hasConcept C2777093970 @default.
- W68074898 hasConcept C2777622882 @default.
- W68074898 hasConcept C519581460 @default.
- W68074898 hasConcept C86803240 @default.
- W68074898 hasConceptScore W68074898C12554922 @default.
- W68074898 hasConceptScore W68074898C134018914 @default.
- W68074898 hasConceptScore W68074898C169760540 @default.
- W68074898 hasConceptScore W68074898C178790620 @default.
- W68074898 hasConceptScore W68074898C185592680 @default.
- W68074898 hasConceptScore W68074898C24998067 @default.
- W68074898 hasConceptScore W68074898C2777093970 @default.
- W68074898 hasConceptScore W68074898C2777622882 @default.
- W68074898 hasConceptScore W68074898C519581460 @default.
- W68074898 hasConceptScore W68074898C86803240 @default.
- W68074898 hasIssue "5" @default.
- W68074898 hasLocation W680748981 @default.
- W68074898 hasOpenAccess W68074898 @default.
- W68074898 hasPrimaryLocation W680748981 @default.
- W68074898 hasRelatedWork W139630520 @default.
- W68074898 hasRelatedWork W1993703402 @default.
- W68074898 hasRelatedWork W2056358456 @default.
- W68074898 hasRelatedWork W2057394743 @default.
- W68074898 hasRelatedWork W2112640215 @default.
- W68074898 hasRelatedWork W2122095615 @default.
- W68074898 hasRelatedWork W229022319 @default.
- W68074898 hasRelatedWork W2290936322 @default.
- W68074898 hasRelatedWork W2329534657 @default.
- W68074898 hasRelatedWork W2371602709 @default.
- W68074898 hasVolume "39" @default.
- W68074898 isParatext "false" @default.
- W68074898 isRetracted "false" @default.
- W68074898 magId "68074898" @default.
- W68074898 workType "article" @default.