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• W68162502 abstract "Neonatal encephalopathy (NE) secondary to intrapartum asphyxia remains a major cause of post-natal death and permanent neurological deficits worldwide. Supportive therapy has been the mainstay of the treatment until recent series of large clinical trials demonstrating benefit of therapeutic hypothermia (TH) in this high risk population. Now the International Liaison Committee on Resuscitation (ILCOR) recommends TH as a standard of care with the protocols used in the large clinical trials as tentative standard protocols. Our goal is to develop a nationwide consensus practice guideline not only consistent with the international standard protocols but also practical and compatible with the current medical system in Japan. In summary, TH should be offered to newborn infants born ⩾36 weeks gestational age and birth weight ⩾1800 g exhibiting clinical signs of moderate to severe NE as well as evidence of hypoxia–ischemia, i.e. 10 min Apgar score ⩽5, a need for resuscitation at 10 min, blood pH < 7.00, or base deficit ⩾16 mmol/L. TH should be conducted in the NICUs capable of multidisciplinary care and under the standard protocols, i.e. utilization of cooling device, target (rectal or esophageal) temperatures at 33.5 ± 0.5 and 34.5 ± 0.5 °C for whole body and selective head cooling respectively, duration of TH for 72 h, gradual rewarming not exceeding the rate of 0.5 °C/h. Long term follow-up with multidisciplinary approach including standardized psychological assessment is warranted." @default.
• W68162502 created "2016-06-24" @default.
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• W68162502 date "2012-02-01" @default.
• W68162502 modified "2023-10-18" @default.
• W68162502 title "Therapeutic hypothermia for neonatal encephalopathy: JSPNM & MHLW Japan Working Group Practice Guidelines" @default.
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• W68162502 doi "https://doi.org/10.1016/j.braindev.2011.06.009" @default.
• W68162502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21930356" @default.
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