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- W68228488 abstract "Local gene therapy offers the potential advantage of confined and prolonged overexpression of inhibitors at defined sites (1–5). As such, it provides a challenging alternative for cytokine-directed targeting in chronic arthritides, where systemic administration of neutralizing antibodies and engineered soluble receptors is now accepted as a promising therapeutic modality. It was recently demonstrated that the cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) play a key role in the process of chronic arthritis and concomitant cartilage and bone destruction. Suppression of TNF and IL-1 yielded relief of symptoms and reduced joint destruction in rheumatoid arthritis (RA) patients. However, these cytokines also have a significant role in hostdefense mechanisms, for instance, in control of infections and tumor growth, implying that it remains a general risk to reduce TNF and IL-1 by systemic treatment for prolonged periods of time." @default.
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- W68228488 date "2002-01-01" @default.
- W68228488 modified "2023-09-23" @default.
- W68228488 title "Gene Therapy in Murine Arthritis" @default.
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- W68228488 doi "https://doi.org/10.1007/978-1-59259-239-5_34" @default.
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