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• W68283852 abstract "Adenocarcinoma of the breast is one of the leading causes of cancer morbidity and mortality among women worldwide. In the United States alone, there are more than 200,000 newly diagnosed cases of invasive breast cancer and in excess of 40,000 cancer-related deaths each year. When a new diagnosis of breast cancer is made, the most immediate issues for each patient involve what the diagnosis means for her future, whether or not she will survive, and whether therapies beyond primary surgery might be of additional benefit. There has been an encouraging decline in mortality from breast cancer over the past years, which can be attributed to several factors, likely largely related to public education and screening programs that lead to the discovery of the disease at an earlier and more treatable stage. In addition, there have been several significant and important treatment advances, with improvements in hormonal therapies, the development of more effective combination chemotherapy regimens, and the development of biologic therapeutics such as the targeted therapy against the human epidermal growth factor receptor 2 ( HER2 ) receptor tyrosine kinase. This evolution of therapeutic modalities for breast cancer has yielded an increasingly complex array of treatment options, both local and systemic, necessitating the development of some rational way of stratifying patients as to the most appropriate treatment regimen based on an assessment of the likelihood for disease recurrence after completion of local–regional therapy." @default.
• W68283852 created "2016-06-24" @default.
• W68283852 creator A5075171048 @default.
• W68283852 date "2009-01-01" @default.
• W68283852 modified "2023-10-14" @default.
• W68283852 title "Molecular Pathology of Breast Cancer" @default.
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• W68283852 doi "https://doi.org/10.1016/b978-044306901-7.50032-8" @default.
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