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- W68322619 abstract "Our previous studies have shown that carcinogens (chemical or physical) induce an enhancement of anchorage-independent (AI) survival in aggregate form, a premalignant phenotype in retrovirus-infected Fischer rat embryo (RIFRE) cells. A specific role for the nontransforming retrovirus genome has been shown in the expression of AI survival: uninfected Fischer rat embryo (FRE) cells are relatively unresponsive to treatment with chemical carcinogens, whereas RIFRE cells are highly responsive. However, exposure of FRE cells to increasing doses (500–2000 uJ/cm2) of ultraviolet (UV) irradiation induced AI survival dose dependently. Cells isolated in aggregate form were allowed to reattach and, upon reaching confluency, were subcultured. The replated UV-exposed cells subsequently showed changes in their cellular morphology as well as growth in semisolid agar, indicating their neoplastic potential. In an attempt to explain the enhanced cell survival in FRE cells following their exposure to UV, the cells were assayed for the presence of endogenous retrovirus by immunofluorescence. The FRE cells were exposed to UV, refed on supplemented media, and the presence of virus was antigenically determined with goat anti-Moloney virus. Endogenous retrovirus expression was detected dose-dependently at similar UV exposure levels used in the expression of increased cellular Al survival. The results show that UV-induced activation of endogenous retrovirus expression in rat embryo cells is associated with the induction of AI survival, a phenotype that precedes the acquisition of morphological or neoplastic transformation." @default.
- W68322619 created "2016-06-24" @default.
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- W68322619 date "1985-01-01" @default.
- W68322619 modified "2023-09-23" @default.
- W68322619 title "Association of Ultraviolet-Induced Retrovirus Expression with Anchorage-Independent Survival in Rat Embryo Cells" @default.
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- W68322619 doi "https://doi.org/10.1007/978-1-4612-5008-1_18" @default.
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