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- W68473398 abstract "This chapter reviews and discusses the clinical use of fluoride for established osteoporosis. It discusses the current information regarding the molecular mechanism of the action of fluoride, and the advantages and disadvantages of fluoride therapy. It has been well recognized for decades that fluoride has both beneficial and detrimental effects on the skeleton. On one hand, it is well documented that fluoride is a bone cell-specific, anabolic agent that effectively stimulates cancellous bone formation and increases spinal bone density without an increase in bone resorption. On the other hand, studies have also demonstrated that fluoride may cause calcium deficiency and osteomalacia, which reduces the integrity of bone, and that high bone deposition of fluoride could greatly reduce the biomechanical properties and strength of the skeleton. These undesirable side effects, together, significantly reduce the benefit-to-risk profile of fluoride therapy and thereby diminish its therapeutic values. However, at present, fluoride is the only orally active, bonespecific, anabolic agent that increases bone formation and bone density at appropriate skeletal sites, that is, trabecular and cortical–endosteal bone sites." @default.
- W68473398 created "2016-06-24" @default.
- W68473398 creator A5024383216 @default.
- W68473398 creator A5044634134 @default.
- W68473398 date "1999-01-01" @default.
- W68473398 modified "2023-09-27" @default.
- W68473398 title "Fluoride Therapy of Established Osteoporosis" @default.
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