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- W68480314 abstract "Acetone has been found to markedly enhance the microsomal hydroxylation of aniline when added to incubation mixtures in concentrations of 0.45 to 1.8 M. The effect occurs in microsomal fractions of rat, mouse, rabbit and dog livers. In addition to enhancing the hydroxylation of aniline, acetone also stimulated the hydroxylation of acetanilide and N-butylaniline but not the N-dealkylation of ethylmorphine, N-methylaniline or N,N-dimethylaniline nor the O-dealkylation of p-nitroanisole. Furthermore, acetone altered the kinetics of aniline hydroxylation and the enhancement was dependent on the pH of the medium. Ethyl isocyanide, a compound known to stimulate aniline hydroxylation by rabbit liver microsomes, has been shown to produce its effects by a mechanism different from that of acetone." @default.
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- W68480314 date "1969-01-01" @default.
- W68480314 modified "2023-09-26" @default.
- W68480314 title "STIMULATORY EFFECT OF ACETONE ON THE ACTIVITY OF MICROSOMAL ANILINE PARA-HYDROXYLASE" @default.
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- W68480314 doi "https://doi.org/10.1016/b978-1-4832-3223-2.50032-x" @default.
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