Matches in SemOpenAlex for { <https://semopenalex.org/work/W68555715> ?p ?o ?g. }
- W68555715 endingPage "112" @default.
- W68555715 startingPage "87" @default.
- W68555715 abstract "G-protein-coupled receptors, or GPCRs, constitute the largest class of plasma membrane receptors. The ubiquity and variety of GPCRs enable cells to fine-tune physiological processes in response to extracellular stimuli. The heart alone contains over 200 types of GPCRs that regulate important functions ranging from myocyte contractility to gene transcription. During cardiac pathologies, however, aberrant or excessive signaling from many of the common cardiac GPCRs contributes to the characteristic pathophysiology that drives disease progression. Despite our increased understanding of the mechanisms underlying GPCR signaling, cardiovascular disease remains a leading cause of death and disability worldwide. Herein, we present the major cardiac GPCRs regulating cardiac function, particularly β-adrenergic and angiotensin II receptors. We also highlight the complexity of signaling pathways initiated by these GPCRs and describe how they mediate many pathological processes. Finally, activation of non-classical signaling cascades are discussed in the context of exploiting such mechanistic insight to develop the next generation of therapeutics for heart disease." @default.
- W68555715 created "2016-06-24" @default.
- W68555715 creator A5011264996 @default.
- W68555715 creator A5017838482 @default.
- W68555715 creator A5023350614 @default.
- W68555715 creator A5036912514 @default.
- W68555715 creator A5065740850 @default.
- W68555715 date "2012-01-01" @default.
- W68555715 modified "2023-09-27" @default.
- W68555715 title "G-Protein-Coupled Receptors in the Heart" @default.
- W68555715 cites W1503765703 @default.
- W68555715 cites W1508835002 @default.
- W68555715 cites W1540099187 @default.
- W68555715 cites W1550053345 @default.
- W68555715 cites W1559798894 @default.
- W68555715 cites W1591510379 @default.
- W68555715 cites W1591546168 @default.
- W68555715 cites W1601710257 @default.
- W68555715 cites W1603274157 @default.
- W68555715 cites W1698053015 @default.
- W68555715 cites W1740028358 @default.
- W68555715 cites W180946569 @default.
- W68555715 cites W1813207029 @default.
- W68555715 cites W1825353903 @default.
- W68555715 cites W1908561802 @default.
- W68555715 cites W1964222441 @default.
- W68555715 cites W1965742222 @default.
- W68555715 cites W1966043663 @default.
- W68555715 cites W1967214804 @default.
- W68555715 cites W1967290172 @default.
- W68555715 cites W1967561584 @default.
- W68555715 cites W1968202984 @default.
- W68555715 cites W1968874083 @default.
- W68555715 cites W1970516435 @default.
- W68555715 cites W1970592808 @default.
- W68555715 cites W1971687277 @default.
- W68555715 cites W1972513389 @default.
- W68555715 cites W1972962885 @default.
- W68555715 cites W1973058394 @default.
- W68555715 cites W1974159422 @default.
- W68555715 cites W1974814786 @default.
- W68555715 cites W1975237053 @default.
- W68555715 cites W1976555160 @default.
- W68555715 cites W1977584503 @default.
- W68555715 cites W1978018445 @default.
- W68555715 cites W1978443526 @default.
- W68555715 cites W1979460197 @default.
- W68555715 cites W1980445909 @default.
- W68555715 cites W1982536356 @default.
- W68555715 cites W1983074420 @default.
- W68555715 cites W1985826042 @default.
- W68555715 cites W1986097078 @default.
- W68555715 cites W1987478872 @default.
- W68555715 cites W1988215184 @default.
- W68555715 cites W1989226644 @default.
- W68555715 cites W1989282030 @default.
- W68555715 cites W1990224341 @default.
- W68555715 cites W1991227176 @default.
- W68555715 cites W1991339265 @default.
- W68555715 cites W1991620824 @default.
- W68555715 cites W1993717649 @default.
- W68555715 cites W1994103758 @default.
- W68555715 cites W1995078408 @default.
- W68555715 cites W1995261878 @default.
- W68555715 cites W1996538078 @default.
- W68555715 cites W1996827499 @default.
- W68555715 cites W1998245427 @default.
- W68555715 cites W2000014503 @default.
- W68555715 cites W2000320049 @default.
- W68555715 cites W2000521278 @default.
- W68555715 cites W2001261561 @default.
- W68555715 cites W2002718782 @default.
- W68555715 cites W2003320070 @default.
- W68555715 cites W2003419547 @default.
- W68555715 cites W2004650590 @default.
- W68555715 cites W2005558025 @default.
- W68555715 cites W2005868264 @default.
- W68555715 cites W2005949023 @default.
- W68555715 cites W2006788480 @default.
- W68555715 cites W2007349364 @default.
- W68555715 cites W2008637244 @default.
- W68555715 cites W2009308756 @default.
- W68555715 cites W2010031713 @default.
- W68555715 cites W2010688793 @default.
- W68555715 cites W2011309117 @default.
- W68555715 cites W2013658571 @default.
- W68555715 cites W2014282173 @default.
- W68555715 cites W2015711125 @default.
- W68555715 cites W2016677731 @default.
- W68555715 cites W2017939520 @default.
- W68555715 cites W2018215013 @default.
- W68555715 cites W2018257569 @default.
- W68555715 cites W2018493611 @default.
- W68555715 cites W2018773000 @default.
- W68555715 cites W2019742616 @default.
- W68555715 cites W2021006625 @default.
- W68555715 cites W2022576341 @default.
- W68555715 cites W2023184753 @default.