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- W68591885 abstract "Research Article15 December 1994free access Regulated degradation of the transcription factor Gcn4. D. Kornitzer D. Kornitzer Whitehead Institute, Nine Cambridge Center, MA 02142. Search for more papers by this author B. Raboy B. Raboy Whitehead Institute, Nine Cambridge Center, MA 02142. Search for more papers by this author R.G. Kulka R.G. Kulka Whitehead Institute, Nine Cambridge Center, MA 02142. Search for more papers by this author G.R. Fink G.R. Fink Whitehead Institute, Nine Cambridge Center, MA 02142. Search for more papers by this author D. Kornitzer D. Kornitzer Whitehead Institute, Nine Cambridge Center, MA 02142. Search for more papers by this author B. Raboy B. Raboy Whitehead Institute, Nine Cambridge Center, MA 02142. Search for more papers by this author R.G. Kulka R.G. Kulka Whitehead Institute, Nine Cambridge Center, MA 02142. Search for more papers by this author G.R. Fink G.R. Fink Whitehead Institute, Nine Cambridge Center, MA 02142. Search for more papers by this author Author Information D. Kornitzer1, B. Raboy1, R.G. Kulka1 and G.R. Fink1 1Whitehead Institute, Nine Cambridge Center, MA 02142. The EMBO Journal (1994)13:6021-6030https://doi.org/10.1002/j.1460-2075.1994.tb06948.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We report that Gcn4, a yeast transcriptional activator of the bZIP family involved in the regulation of the biosynthesis of amino acids and purines, is rapidly turned over. This degradation is inhibited under conditions of starvation for amino acids. Degradation is also inhibited by single amino acid alterations in a region adjacent to the Gcn4 activation domain. Furthermore, we show that degradation of Gcn4 proceeds through the ubiquitin pathway, a major proteolytic system for cytoplasmic proteins, and is dependent on two specific ubiquitin conjugating enzymes, Cdc34 (Ubc3) and Rad6 (Ubc2). As a first step towards reconstituting the Gcn4 degradation pathway in vitro, we show that purified Cdc34 and Rad6 proteins are able to direct the specific ubiquitination of Gcn4. Previous ArticleNext Article Volume 13Issue 241 December 1994In this issue RelatedDetailsLoading ..." @default.
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- W68591885 title "Regulated degradation of the transcription factor Gcn4." @default.
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