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• W68605413 endingPage "214" @default.
• W68605413 startingPage "199" @default.
• W68605413 abstract "Cancer is one of the diseases in which a role has been implicated for free radicals. It is well established that aerobes constantly produce small amounts of oxygen-derived species—such as the superoxide radical (O2-), hydrogen peroxide (H202), and hypochlorous acid (HOCI)—with HOCI being generated by the enzyme myeloperoxidase in neutrophils. DNA damage has been almost invariably observed in a wide range of mammalian cell types exposed to oxidative stress in a number of different ways. Oxidative stress and DNA damage also occur when some mammalian cells are exposed to tumor necrosis factors. This chapter presents the two explanations of the DNA damage that have been advanced. First, it is possible that the damage is because of ͦOH radical formation. Thus, it is envisaged that H202, which crosses biological membranes easily, can penetrate to the nucleus and react with iron or copper ions to form ͦOH. A second explanation of the ability of oxidative stress to cause DNA damage is that the stress triggers a series of metabolic events within the cell that lead to the activation of nuclease enzymes, which cleave the DNA backbone." @default.
• W68605413 created "2016-06-24" @default.
• W68605413 creator A5053726981 @default.
• W68605413 creator A5067970209 @default.
• W68605413 date "1995-01-01" @default.
• W68605413 modified "2023-10-16" @default.
• W68605413 title "DNA Damage by Free Radicals" @default.
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