Matches in SemOpenAlex for { <https://semopenalex.org/work/W68686450> ?p ?o ?g. }
- W68686450 endingPage "87" @default.
- W68686450 startingPage "174" @default.
- W68686450 abstract "The epidemic of overweight and obesity is a major problem because of the plethora of health and economic issues that it induces. Key among these is the sharply increasing prevalence of type 2 diabetes (T2D) and cardiovascular disease. The development of T2D is characterised by two processes: 1) insulin resistance, resulting from impaired insulin signalling and leading to an increased demand for insulin, which must be met by increased insulin production by pancreatic β-cells (compensatory β-cell function); and 2) β-cell dysfunction, with T2D developing when the amount of insulin that is produced is insufficient to meet the demand. Overweight and obesity, especially in case of abdominal fat accumulation, are associated with systemic low-grade inf lammation. This low-grade inf lammation is characterised by, among other things, higher levels of circulating proinflammatory cytokines and fatty acids. These can interfere with normal insulin function and thereby induce insulin resistance, and have also been implicated in β-cell dysfunction. This review focuses on the known and emerging relations between inflammation and T2D. We first discuss current views on the effects of fat distribution on adipose tissue inflammation and adipose tissue dysfunction. Next we focus on the detrimental roles of proinflammatory cytokines and fatty acids on insulin signalling and β-cell function. In the last part of this review we provide some insight into novel players in (the initiation of) inflammation in overweight and obesity, and their effects on T2D and vascular dysfunction." @default.
- W68686450 created "2016-06-24" @default.
- W68686450 creator A5023966597 @default.
- W68686450 creator A5027732336 @default.
- W68686450 creator A5031265369 @default.
- W68686450 date "2013-05-01" @default.
- W68686450 modified "2023-09-23" @default.
- W68686450 title "Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences." @default.
- W68686450 cites W1512522692 @default.
- W68686450 cites W1521975179 @default.
- W68686450 cites W1547435373 @default.
- W68686450 cites W1567156395 @default.
- W68686450 cites W1570453996 @default.
- W68686450 cites W1572110929 @default.
- W68686450 cites W1581065404 @default.
- W68686450 cites W1703151364 @default.
- W68686450 cites W1883690383 @default.
- W68686450 cites W1892916724 @default.
- W68686450 cites W1943668942 @default.
- W68686450 cites W1964714465 @default.
- W68686450 cites W1965120293 @default.
- W68686450 cites W1966336914 @default.
- W68686450 cites W1966342280 @default.
- W68686450 cites W1966788451 @default.
- W68686450 cites W1968003131 @default.
- W68686450 cites W1969047353 @default.
- W68686450 cites W1969060340 @default.
- W68686450 cites W1971701221 @default.
- W68686450 cites W1972504380 @default.
- W68686450 cites W1973450552 @default.
- W68686450 cites W1976184663 @default.
- W68686450 cites W1979513676 @default.
- W68686450 cites W1982640240 @default.
- W68686450 cites W1987265109 @default.
- W68686450 cites W1988870963 @default.
- W68686450 cites W1989762800 @default.
- W68686450 cites W1990456378 @default.
- W68686450 cites W1996560248 @default.
- W68686450 cites W2001054657 @default.
- W68686450 cites W2002711503 @default.
- W68686450 cites W2003659422 @default.
- W68686450 cites W2006313514 @default.
- W68686450 cites W2008869160 @default.
- W68686450 cites W2009465892 @default.
- W68686450 cites W2009897819 @default.
- W68686450 cites W2011594751 @default.
- W68686450 cites W2012650972 @default.
- W68686450 cites W2013898467 @default.
- W68686450 cites W2014051267 @default.
- W68686450 cites W2014141074 @default.
- W68686450 cites W2015038984 @default.
- W68686450 cites W2015823886 @default.
- W68686450 cites W2022420894 @default.
- W68686450 cites W2022930571 @default.
- W68686450 cites W2024378513 @default.
- W68686450 cites W2024992738 @default.
- W68686450 cites W2025976180 @default.
- W68686450 cites W2029632724 @default.
- W68686450 cites W2030526970 @default.
- W68686450 cites W2030977583 @default.
- W68686450 cites W2034098218 @default.
- W68686450 cites W2034541077 @default.
- W68686450 cites W2036308824 @default.
- W68686450 cites W2037519948 @default.
- W68686450 cites W2037585741 @default.
- W68686450 cites W2037884311 @default.
- W68686450 cites W2037892222 @default.
- W68686450 cites W2038908268 @default.
- W68686450 cites W2041448730 @default.
- W68686450 cites W2041544510 @default.
- W68686450 cites W2041717886 @default.
- W68686450 cites W2042077424 @default.
- W68686450 cites W2042134458 @default.
- W68686450 cites W2047442471 @default.
- W68686450 cites W2048032544 @default.
- W68686450 cites W2048211245 @default.
- W68686450 cites W2048554655 @default.
- W68686450 cites W2048970664 @default.
- W68686450 cites W2049117288 @default.
- W68686450 cites W2052502118 @default.
- W68686450 cites W2054027245 @default.
- W68686450 cites W2054479980 @default.
- W68686450 cites W2054960635 @default.
- W68686450 cites W2056598101 @default.
- W68686450 cites W2058154833 @default.
- W68686450 cites W2065201220 @default.
- W68686450 cites W2065654211 @default.
- W68686450 cites W2065789432 @default.
- W68686450 cites W2066006065 @default.
- W68686450 cites W2066290080 @default.
- W68686450 cites W2066600483 @default.
- W68686450 cites W2066963386 @default.
- W68686450 cites W2070390509 @default.
- W68686450 cites W2071450001 @default.
- W68686450 cites W2073185462 @default.
- W68686450 cites W2073657429 @default.
- W68686450 cites W2073959976 @default.
- W68686450 cites W2074417825 @default.