Matches in SemOpenAlex for { <https://semopenalex.org/work/W68691347> ?p ?o ?g. }
- W68691347 abstract "Granulocyte-macrophage colony-stimulating factor (GM-CSF) is produced by a variety of cells at sites of exposure to antigens. GM-CSF has a stimulatory effect on a number of neutrophil functions, but the effect on macrophage function is less clear. We investigated the effect of purified murine recombinant GM-CSF on murine peritoneal macrophage oxidative metabolism, Fc-dependent phagocytosis, anti-Toxoplasma activity, and expression of class II major histocompatibility antigen (Iad). GM-CSF significantly increased phorbol myristate acetate- and zymosan-elicited H2O2 release by resident and thioglycollate-elicited macrophages after 48 hours in vitro. The effect of recombinant GM-CSF was blocked by polyclonal anti-GM-CSF antibody and was not altered by lipopolysaccharide (0.01 to 1.0 microgram/mL). GM-CSF also stimulated Fc-dependent phagocytosis by peritoneal macrophages, although the stimulation of resident macrophages (1.4-fold) was less dramatic than that of thioglycollate-elicited cells (2.1-fold). GM-CSF (at doses up to 100 U/mL) had no effect on macrophage anti-Toxoplasma activity or on expression of Iad. In addition to stimulating macrophage growth, GM-CSF selectively promotes the functional capacity of tissue-derived macrophages." @default.
- W68691347 created "2016-06-24" @default.
- W68691347 creator A5005447367 @default.
- W68691347 creator A5038307269 @default.
- W68691347 creator A5051981252 @default.
- W68691347 creator A5075285906 @default.
- W68691347 date "1988-08-01" @default.
- W68691347 modified "2023-10-01" @default.
- W68691347 title "Granulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophages" @default.
- W68691347 cites W109806090 @default.
- W68691347 cites W1488430518 @default.
- W68691347 cites W1505476215 @default.
- W68691347 cites W1510477151 @default.
- W68691347 cites W1522352873 @default.
- W68691347 cites W1541007861 @default.
- W68691347 cites W1585358225 @default.
- W68691347 cites W1591899727 @default.
- W68691347 cites W1595995853 @default.
- W68691347 cites W1605811717 @default.
- W68691347 cites W1675276494 @default.
- W68691347 cites W1775749144 @default.
- W68691347 cites W1807169956 @default.
- W68691347 cites W1917885853 @default.
- W68691347 cites W1973034088 @default.
- W68691347 cites W1974401900 @default.
- W68691347 cites W1981227067 @default.
- W68691347 cites W1998680279 @default.
- W68691347 cites W1999243294 @default.
- W68691347 cites W2002707966 @default.
- W68691347 cites W2014042634 @default.
- W68691347 cites W2035390621 @default.
- W68691347 cites W2044819628 @default.
- W68691347 cites W2045281985 @default.
- W68691347 cites W2047605080 @default.
- W68691347 cites W2050660793 @default.
- W68691347 cites W2076940976 @default.
- W68691347 cites W2087568391 @default.
- W68691347 cites W2105099043 @default.
- W68691347 cites W2106639420 @default.
- W68691347 cites W2106992189 @default.
- W68691347 cites W2140985128 @default.
- W68691347 cites W2141715517 @default.
- W68691347 cites W2142736773 @default.
- W68691347 cites W2143162403 @default.
- W68691347 cites W2145090129 @default.
- W68691347 cites W2158528246 @default.
- W68691347 cites W2160040629 @default.
- W68691347 cites W2163498187 @default.
- W68691347 cites W2174403165 @default.
- W68691347 cites W2317007280 @default.
- W68691347 cites W72369317 @default.
- W68691347 cites W2102626808 @default.
- W68691347 doi "https://doi.org/10.1182/blood.v72.2.573.bloodjournal722573" @default.
- W68691347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3042043" @default.
- W68691347 hasPublicationYear "1988" @default.
- W68691347 type Work @default.
- W68691347 sameAs 68691347 @default.
- W68691347 citedByCount "38" @default.
- W68691347 countsByYear W686913472013 @default.
- W68691347 countsByYear W686913472014 @default.
- W68691347 countsByYear W686913472015 @default.
- W68691347 countsByYear W686913472017 @default.
- W68691347 countsByYear W686913472020 @default.
- W68691347 countsByYear W686913472021 @default.
- W68691347 countsByYear W686913472023 @default.
- W68691347 crossrefType "journal-article" @default.
- W68691347 hasAuthorship W68691347A5005447367 @default.
- W68691347 hasAuthorship W68691347A5038307269 @default.
- W68691347 hasAuthorship W68691347A5051981252 @default.
- W68691347 hasAuthorship W68691347A5075285906 @default.
- W68691347 hasBestOaLocation W686913471 @default.
- W68691347 hasConcept C109159458 @default.
- W68691347 hasConcept C147483822 @default.
- W68691347 hasConcept C153911025 @default.
- W68691347 hasConcept C160448771 @default.
- W68691347 hasConcept C202751555 @default.
- W68691347 hasConcept C203014093 @default.
- W68691347 hasConcept C2777478134 @default.
- W68691347 hasConcept C2777983669 @default.
- W68691347 hasConcept C2778690821 @default.
- W68691347 hasConcept C2778754761 @default.
- W68691347 hasConcept C2778870864 @default.
- W68691347 hasConcept C2779244956 @default.
- W68691347 hasConcept C28328180 @default.
- W68691347 hasConcept C49382859 @default.
- W68691347 hasConcept C50442881 @default.
- W68691347 hasConcept C55493867 @default.
- W68691347 hasConcept C64921476 @default.
- W68691347 hasConcept C7244527 @default.
- W68691347 hasConcept C86803240 @default.
- W68691347 hasConcept C880424 @default.
- W68691347 hasConcept C95444343 @default.
- W68691347 hasConceptScore W68691347C109159458 @default.
- W68691347 hasConceptScore W68691347C147483822 @default.
- W68691347 hasConceptScore W68691347C153911025 @default.
- W68691347 hasConceptScore W68691347C160448771 @default.
- W68691347 hasConceptScore W68691347C202751555 @default.
- W68691347 hasConceptScore W68691347C203014093 @default.
- W68691347 hasConceptScore W68691347C2777478134 @default.
- W68691347 hasConceptScore W68691347C2777983669 @default.