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- W68816448 abstract "Currently, bioprosthetic heart valves are crosslinked with glutaraldehyde to prevent tissue degradation and to reduce tissue antigenicity. Glutaraldehyde forms stable crosslinks with collagen via a Schiff base reaction of the aldehyde with an amine group of the hydroxylysine/lysine in collagen. However, within a decade of implantation, 2030% of these bioprostheses will become dysfunctional and over 50% will fail due to degeneration within 12-15 years post-operatively [1, 2]. Gylcosaminoglycans, a major constituent of valvular tissue, play an important role in maintaining a hydrated environment necessary for absorbing compressive loads, modulating shear stresses, and resisting tissue buckling. One of the disadvantages of glutaraldehyde crosslinking is its incomplete stabilization of GAGs [3, 4], which lack the amine functionalities necessary for fixation by aldehyde addition. Previous studies have reported a greater depth of buckling in glutaraldehyde crosslinked aortic valves, one of the major causes of failure in these bioprostheses [5, 6]. Buckling occurs at sites of sharp bending, producing large stresses that can eventually lead to mechanical fatigue and consequent valvular degeneration. Local structural collapse occurs at these areas of tissue buckling to minimize compressive stresses, which subsequently causes a reduction in tissue length. Previous studies have reported the loss of GAGs in glutaraldehyde crosslinked porcine cusps during fixation, storage, in vitro fatigue experimentation, and in vivo subdermal implantation due to enzyme-mediated GAG degradation [3, 4, 7, 8]." @default.
- W68816448 created "2016-06-24" @default.
- W68816448 creator A5075155980 @default.
- W68816448 date "2007-01-01" @default.
- W68816448 modified "2023-09-27" @default.
- W68816448 title "Glycosaminoglycan Stabilization Reduces Tissue Buckling in Bioprosthetic Heart Valves" @default.
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