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- W68854549 endingPage "361" @default.
- W68854549 startingPage "335" @default.
- W68854549 abstract "The recent years have witnessed an exponential growth in the knowledge of epigenetic mechanisms, and piling evidence now links DNA methylation and histone modifications with a wide range of physiological processes from embryonic development to memory formation and behavior. Not surprisingly, deregulation of epigenetic modifications is associated with human diseases as well.An important feature of epigenetics is the ability of transducing environmental input into biological signaling, mainly by modulation of the transcriptome in response to a particular scenario. This characteristic generates developmental plasticity and allows the manifestation of a variety of phenotypes from the same genome.The early-life years represent a period of particular susceptibility to epigenetic alteration, as active changes in DNA methylation and histone marks are occurring as part of developmental programs and in response to environmental cues, which notably include psychosocial stimulation and maternal behavior. Memory formation and storage, response to stress in adult life, behavior, and manifestation of neurodegenerative conditions can all be imprinted in the organism by epigenetic modifications that contribute to shape the brain during prenatal or early postnatal life. Moreover, if these epigenetic alterations are preserved in the germ line, changes induced in one generation are likely inherited by future offspring. Programming by transgenerational inheritance thus represents a central mechanism by which environmental conditions may influence disease risk across multiple generations.As novel techniques emerge and as genome-wide profiling of disease-associated methylomes is achieved, epigenetic marks open a new source for biomarker discovery." @default.
- W68854549 created "2016-06-24" @default.
- W68854549 creator A5058385646 @default.
- W68854549 date "2014-10-07" @default.
- W68854549 modified "2023-09-25" @default.
- W68854549 title "Perinatal Programming of Neurodevelopment: Epigenetic Mechanisms and the Prenatal Shaping of the Brain" @default.
- W68854549 cites W1536700299 @default.
- W68854549 cites W1545480326 @default.
- W68854549 cites W1547045190 @default.
- W68854549 cites W1577875429 @default.
- W68854549 cites W1592069930 @default.
- W68854549 cites W1597656413 @default.
- W68854549 cites W1758186940 @default.
- W68854549 cites W191075349 @default.
- W68854549 cites W1934033863 @default.
- W68854549 cites W1964768515 @default.
- W68854549 cites W1965636455 @default.
- W68854549 cites W1967727160 @default.
- W68854549 cites W1967769642 @default.
- W68854549 cites W1967841068 @default.
- W68854549 cites W1969021739 @default.
- W68854549 cites W1972943884 @default.
- W68854549 cites W1974473791 @default.
- W68854549 cites W1977087590 @default.
- W68854549 cites W1980782305 @default.
- W68854549 cites W1981463058 @default.
- W68854549 cites W1982354720 @default.
- W68854549 cites W1982857619 @default.
- W68854549 cites W1982925999 @default.
- W68854549 cites W1983581469 @default.
- W68854549 cites W1984427714 @default.
- W68854549 cites W1984703718 @default.
- W68854549 cites W1987261189 @default.
- W68854549 cites W1992903566 @default.
- W68854549 cites W1994674729 @default.
- W68854549 cites W1995470989 @default.
- W68854549 cites W1996362121 @default.
- W68854549 cites W1997184565 @default.
- W68854549 cites W1997453048 @default.
- W68854549 cites W1997904391 @default.
- W68854549 cites W1998442739 @default.
- W68854549 cites W1999874171 @default.
- W68854549 cites W2001711719 @default.
- W68854549 cites W2008201324 @default.
- W68854549 cites W2009252034 @default.
- W68854549 cites W2009582310 @default.
- W68854549 cites W2011988545 @default.
- W68854549 cites W2013245174 @default.
- W68854549 cites W2013571070 @default.
- W68854549 cites W2014212152 @default.
- W68854549 cites W2017034268 @default.
- W68854549 cites W2017936139 @default.
- W68854549 cites W2018800004 @default.
- W68854549 cites W2021052829 @default.
- W68854549 cites W2021280064 @default.
- W68854549 cites W2023448665 @default.
- W68854549 cites W2025613570 @default.
- W68854549 cites W2026524250 @default.
- W68854549 cites W2028188824 @default.
- W68854549 cites W2038449573 @default.
- W68854549 cites W2038989464 @default.
- W68854549 cites W2040506727 @default.
- W68854549 cites W2043662856 @default.
- W68854549 cites W2044345769 @default.
- W68854549 cites W2048637593 @default.
- W68854549 cites W2050005460 @default.
- W68854549 cites W2051483319 @default.
- W68854549 cites W2052665087 @default.
- W68854549 cites W2052714177 @default.
- W68854549 cites W2053901332 @default.
- W68854549 cites W2054017008 @default.
- W68854549 cites W2054643318 @default.
- W68854549 cites W2054692302 @default.
- W68854549 cites W2054776840 @default.
- W68854549 cites W2055214702 @default.
- W68854549 cites W2055386916 @default.
- W68854549 cites W2055874717 @default.
- W68854549 cites W2057997718 @default.
- W68854549 cites W2064804693 @default.
- W68854549 cites W2064861163 @default.
- W68854549 cites W2065406720 @default.
- W68854549 cites W2066017487 @default.
- W68854549 cites W2069892841 @default.
- W68854549 cites W2071213636 @default.
- W68854549 cites W2073518622 @default.
- W68854549 cites W2077798470 @default.
- W68854549 cites W2083225704 @default.
- W68854549 cites W2085926540 @default.
- W68854549 cites W2090760765 @default.
- W68854549 cites W2090999212 @default.
- W68854549 cites W2091602444 @default.
- W68854549 cites W2091796012 @default.
- W68854549 cites W2091811407 @default.
- W68854549 cites W2091987951 @default.
- W68854549 cites W2092765329 @default.
- W68854549 cites W2101037833 @default.
- W68854549 cites W2102926673 @default.
- W68854549 cites W2104471815 @default.