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- W68990060 abstract "Objective To investigate the potential influence of interleukin(IL)-12 on histamine release from the mast cells and posible signal transduction pathways. Methods After the mast cells(P815) were stimulated and cultured, the cells and supernatant were collected for detecting IL-4, IL-6 and histamine by enzyme-linked immunosorbent assay(ELISA). The phosphorylation of ERK, AKT, p38 and STAT3 were measured by cellular activation of signal ELISA(CASE). Results IL-12 induced concentration-dependently the release of IL-4 from P815 cells, but had no effect on the release of IL-4 and histamine. PD98059, U0126 and LY294002 inhibited the IL-12-induced release of IL-4 from P815 cells and phosphorylation of ERK and AKT. Conclusion IL-12-induced IL-4 release from P815 cells is most likely through the activation of AKT and ERK signalling pathways." @default.
- W68990060 created "2016-06-24" @default.
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- W68990060 date "2008-12-10" @default.
- W68990060 modified "2023-09-23" @default.
- W68990060 title "IL-12刺激肥大细胞分泌IL-4与ERK和AKT信号转导通路有关" @default.
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