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- W68993145 abstract "Lithium (Li) is a trace element widely distributed on Earth. Because of its similarity with sodium and potassium, Li easily crosses all biological barriers, meaning that it shows almost complete oral absorption and a uniform distribution in body fluids. Not being protein bound, Li is rapidly eliminated by the kidneys, with almost no tissue accumulation. The main source of Li exposure known to cause toxic effects in human is the use of Li in the treatment of mood disorders. As the therapeutic index of Li is very low, side effects are quite common and mainly consist of a reduced urinary concentration capacity, hypothyroidism, and neurotoxic effects. With the exception perhaps of areas with very high levels of Li in drinking water, there is no evidence that environmental Li may cause adverse effects on the general population. On the contrary, ecological studies increasingly suggest that low-level exposure to natural Li might be beneficial to mental health by preventing violence and depressive states." @default.
- W68993145 created "2016-06-24" @default.
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- W68993145 date "2015-01-01" @default.
- W68993145 modified "2023-09-26" @default.
- W68993145 title "Lithium" @default.
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- W68993145 doi "https://doi.org/10.1016/b978-0-444-59453-2.00044-5" @default.
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