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- W69042955 abstract "The use of probiotic bacteria as an adjuvant has been considered an important strategy to increase the effectiveness of vaccines against several pathogens. Recent work with the adjuvant candidate, Lactobacillus delbrueckii UFV H2b20, described its capacity to induce, in vitro, pro-inflammatory cytokines such as IFN-γ, TNF-α and IL-12 by mouse splenocites and mononuclear peripheral human blood cells. The production of cytokines characteristic of a TH1 immune response was, however, unable to protect BALB/c mice against a Leishmania braziliensis infection, suggesting a possible regulation of the inflammatory process. Based on these observations, we decided to characterize the L. delbrueckii induced response profile, aiming to understand the mechanism involved in the response control. To this aim, we have verified the dead L. delbrueckii stimulation induced pro and anti-inflammatory cytokines production and also CCL2 and CXCL10 chemokines, suggesting that this preparation is probably able to recruit macrophages and NK cells. Toll-like receptors, specifically TLR-2 and TLR-4, were also evaluated as participants in actobacilli recognition and involvement in the subsequent immune response induction. The results of experiments with mouse lineages deficient for these receptors showed an effective participation of TLR-2 receptor only. These results were confirmed by experiments performed with the probiotic wall extract, which the absence of this receptor leaded to a decrease IFN-γ induction. The molecular characterization of this bacterial fraction demonstrated the presence of sugar and lipids in its composition. In summary, our data showed that the studied lactobacilli is able to induce different immunological responses depending on the dose used and that ability is mediated by TLR-2 activation." @default.
- W69042955 created "2016-06-24" @default.
- W69042955 creator A5052023317 @default.
- W69042955 date "2007-01-01" @default.
- W69042955 modified "2023-09-27" @default.
- W69042955 title "Avaliação da participação de receptores do tipo toll na indução de resposta imune por Lactobacillus delbrueckii UFV H2b20 ." @default.
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